2jek
From Proteopedia
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| - | [[Image:2jek.gif|left|200px]]<br /><applet load="2jek" size=" | + | [[Image:2jek.gif|left|200px]]<br /><applet load="2jek" size="350" color="white" frame="true" align="right" spinBox="true" |
caption="2jek, resolution 1.38Å" /> | caption="2jek, resolution 1.38Å" /> | ||
'''CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN RV1873 FROM MYCOBACTERIUM TUBERCULOSIS AT 1.38 A'''<br /> | '''CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN RV1873 FROM MYCOBACTERIUM TUBERCULOSIS AT 1.38 A'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2JEK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with SO4 and GOL as [http://en.wikipedia.org/wiki/ligands ligands]. This structure superseeds the now removed PDB entry 2D2Y. Known structural/functional Site: <scene name='pdbsite=AC1:Gol Binding Site For Chain A'>AC1</scene>. Full crystallographic information is available from [http:// | + | 2JEK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis] with <scene name='pdbligand=SO4:'>SO4</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. This structure superseeds the now removed PDB entry 2D2Y. Known structural/functional Site: <scene name='pdbsite=AC1:Gol+Binding+Site+For+Chain+A'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEK OCA]. |
==Reference== | ==Reference== | ||
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[[Category: unknown function]] | [[Category: unknown function]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:44:53 2008'' |
Revision as of 08:44, 3 February 2008
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CRYSTAL STRUCTURE OF THE CONSERVED HYPOTHETICAL PROTEIN RV1873 FROM MYCOBACTERIUM TUBERCULOSIS AT 1.38 A
Overview
The X-ray crystal structure of the gene product encoded by open reading, frame Rv1873 of Mycobacterium tuberculosis has been determined by single, isomorphous replacement with anomalous scattering (SIRAS) phasing, techniques at 1.38 A resolution from monoclinic crystals with unit-cell, parameters a = 33.44, b = 31.63, c = 53.19 A, beta = 90.8 degrees. The, 16.2 kDa Rv1873 is a monomer that adopts a primarily alpha-helical fold, with limited structural similarity to previously determined tertiary, structures. It has been annotated as a conserved hypothetical protein of, unknown function and is classified by the Clusters of Orthologous Groups, (COG) database as belonging to COG5579. The three-dimensional structure of, the Rv1873 gene product reveals limited similarity to a repeated motif, that is found in a variety of other proteins. While not a novel fold, it, serves as a model for orthologues predicted to be related by sequence and, it is hoped that knowledge of the structure of Rv1873 will aid in, determining a possible function for this protein.
About this Structure
2JEK is a Single protein structure of sequence from Mycobacterium tuberculosis with and as ligands. This structure superseeds the now removed PDB entry 2D2Y. Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The molecular structure of Rv1873, a conserved hypothetical protein from Mycobacterium tuberculosis, at 1.38 A resolution., Garen CR, Cherney MM, Bergmann EM, James MN, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2006 Dec 1;62(Pt, 12):1201-5. Epub 2006 Nov 30. PMID:17142896
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Categories: Mycobacterium tuberculosis | Single protein | Bergmann, E.M. | Cherney, M.M. | Garen, C.R. | James, M.N.G. | TBSGC, TB.Structural.Genomics.Consortium. | GOL | SO4 | Hypothetical protein | Protein structure initiative | Psi | Right-handed superhelix | Structural genomics | Tb structural genomics consortium | Tbsgc | Unknown function
