1iyu
From Proteopedia
(New page: 200px<br /> <applet load="1iyu" size="450" color="white" frame="true" align="right" spinBox="true" caption="1iyu" /> '''LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COM...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1IYU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IYU OCA]]. | + | 1IYU is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Azotobacter_vinelandii Azotobacter vinelandii]]. Active as [[http://en.wikipedia.org/wiki/Dihydrolipoyllysine-residue_acetyltransferase Dihydrolipoyllysine-residue acetyltransferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.12 2.3.1.12]]. Structure known Active Site: LIP. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1IYU OCA]]. |
==Reference== | ==Reference== | ||
Three-dimensional structure in solution of the N-terminal lipoyl domain of the pyruvate dehydrogenase complex from Azotobacter vinelandii., Berg A, Vervoort J, de Kok A, Eur J Biochem. 1997 Mar 1;244(2):352-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9119000 9119000] | Three-dimensional structure in solution of the N-terminal lipoyl domain of the pyruvate dehydrogenase complex from Azotobacter vinelandii., Berg A, Vervoort J, de Kok A, Eur J Biochem. 1997 Mar 1;244(2):352-60. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=9119000 9119000] | ||
[[Category: Azotobacter vinelandii]] | [[Category: Azotobacter vinelandii]] | ||
| + | [[Category: Dihydrolipoyllysine-residue acetyltransferase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Berg, A.]] | [[Category: Berg, A.]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:49:30 2007'' |
Revision as of 10:44, 30 October 2007
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LIPOYL DOMAIN OF PYRUVATE DEHYDROGENASE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
The three-dimensional structure of the N-terminal lipoyl domain of the, acetyltransferase component of the pyruvate dehydrogenase complex from, Azotobacter vinelandii has been determined using heteronuclear, multidimensional NMR spectroscopy and dynamical simulated annealing. The, structure is compared with the solution structure of the lipoyl domain of, the A. vinelandii 2-oxoglutarate dehydrogenase complex. The overall fold, of the two structures, described as a beta-barrel-sandwich hybrid, is very, similar. This agrees well with the high similarity of NMR-derived, parameters, e.g. chemical shifts, between the two lipoyl domains. The main, structural differences between the two lipoyl domains occur in a, solvent-exposed loop close in space to the lipoylation site. Despite their, high ... [(full description)]
About this Structure
1IYU is a [Single protein] structure of sequence from [Azotobacter vinelandii]. Active as [Dihydrolipoyllysine-residue acetyltransferase], with EC number [2.3.1.12]. Structure known Active Site: LIP. Full crystallographic information is available from [OCA].
Reference
Three-dimensional structure in solution of the N-terminal lipoyl domain of the pyruvate dehydrogenase complex from Azotobacter vinelandii., Berg A, Vervoort J, de Kok A, Eur J Biochem. 1997 Mar 1;244(2):352-60. PMID:9119000
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