2uuv
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
| - | 2UUV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] with <scene name='pdbligand=FAD:'>FAD</scene> and <scene name='pdbligand=PL3:'>PL3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Alkylglycerone-phosphate_synthase Alkylglycerone-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.26 2.5.1.26] Known structural/functional Site: <scene name='pdbsite=AC1:Pl3 Binding Site For Chain D'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUV OCA]. | + | 2UUV is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] with <scene name='pdbligand=FAD:'>FAD</scene> and <scene name='pdbligand=PL3:'>PL3</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Alkylglycerone-phosphate_synthase Alkylglycerone-phosphate synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.26 2.5.1.26] Known structural/functional Site: <scene name='pdbsite=AC1:Pl3+Binding+Site+For+Chain+D'>AC1</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2UUV OCA]. |
==Reference== | ==Reference== | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Feb 3 10:47:11 2008'' |
Revision as of 08:47, 3 February 2008
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ALKYLDIHYDROXYACETONEPHOSPHATE SYNTHASE IN P1
Overview
Ether phospholipids are essential constituents of eukaryotic cell, membranes. Rhizomelic chondrodysplasia punctata type 3 is a severe, peroxisomal disorder caused by inborn deficiency of, alkyldihydroxyacetonephosphate synthase (ADPS). The enzyme carries out the, most characteristic step in ether phospholipid biosynthesis: formation of, the ether bond. The crystal structure of ADPS from Dictyostelium, discoideum shows a fatty-alcohol molecule bound in a narrow hydrophobic, tunnel, specific for aliphatic chains of 16 carbons. Access to the tunnel, is controlled by a flexible loop and a gating helix at the, protein-membrane interface. Structural and mutagenesis investigations, identify a cluster of hydrophilic catalytic residues, including an, essential tyrosine, possibly involved in substrate proton abstraction, and, the arginine that is mutated in ADPS-deficient patients. We propose that, ether bond formation might be orchestrated through a covalent imine, intermediate with the flavin, accounting for the noncanonical employment, of a flavin cofactor in a nonredox reaction.
About this Structure
2UUV is a Single protein structure of sequence from Dictyostelium discoideum with and as ligands. Active as Alkylglycerone-phosphate synthase, with EC number 2.5.1.26 Known structural/functional Site: . Full crystallographic information is available from OCA.
Reference
The crucial step in ether phospholipid biosynthesis: structural basis of a noncanonical reaction associated with a peroxisomal disorder., Razeto A, Mattiroli F, Carpanelli E, Aliverti A, Pandini V, Coda A, Mattevi A, Structure. 2007 Jun;15(6):683-92. PMID:17562315
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Categories: Alkylglycerone-phosphate synthase | Dictyostelium discoideum | Single protein | Aliverti, A. | Carpanelli, E. | Coda, A. | Mattevi, A. | Mattiroli, F. | Pandini, V. | Razeto, A. | FAD | PL3 | Biosynthesis of phospholipids | Fad | Flavin | Flavoprotein | Lipid synthesis | Peroxisomal disorder | Peroxisome | Plasmalogens | Rhizomelic chondrodysplasia punctata | Transferase
