2c0t
From Proteopedia
(New page: 200px<br /> <applet load="2c0t" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c0t, resolution 2.15Å" /> '''SRC FAMILY KINASE H...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C0T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA and L3G as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.112 2.7.1.112]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C0T OCA]]. | + | 2C0T is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with CA and L3G as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Transferred_entry:_2.7.10.1_and_2.7.10.2 Transferred entry: 2.7.10.1 and 2.7.10.2]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.112 2.7.1.112]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C0T OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
| + | [[Category: Transferred entry: 2.7.10.1 and 2.7.10.2]] | ||
[[Category: Borhani, D.W.]] | [[Category: Borhani, D.W.]] | ||
[[Category: Burchat, A.]] | [[Category: Burchat, A.]] | ||
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[[Category: tyrosine-protein kinase]] | [[Category: tyrosine-protein kinase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:50:25 2007'' |
Revision as of 10:45, 30 October 2007
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SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359
Overview
We describe the identification, SAR, and pharmacology of the src-family, selective lck inhibitor A-770041 that prolongs the survival of major, histocompatibility mismatched allografts in models of solid organ, transplant rejection for greater than 65 days.
About this Structure
2C0T is a [Single protein] structure of sequence from [Homo sapiens] with CA and L3G as [ligands]. Active as [Transferred entry: 2.7.10.1 and 2.7.10.2], with EC number [2.7.1.112]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497
Page seeded by OCA on Tue Oct 30 12:50:25 2007
Categories: Homo sapiens | Single protein | Transferred entry: 2.7.10.1 and 2.7.10.2 | Borhani, D.W. | Burchat, A. | Calderwood, D.J. | Hirst, G.C. | Li, B. | Loew, A. | CA | L3G | Alternative initiation | Atp-binding | Kinase | Lipoprotein | Myristate | Nucleotide-binding | Palmitate | Phosphorylation | Sh2 domain | Sh3 domain | Transferase | Tyrosine-protein kinase
