2c02
From Proteopedia
(New page: 200px<br /> <applet load="2c02" size="450" color="white" frame="true" align="right" spinBox="true" caption="2c02, resolution 2.00Å" /> '''CRYSTAL STRUCTURES ...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2C02 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ADP and ACY as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C02 OCA]]. | + | 2C02 is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]] with ADP and ACY as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2C02 OCA]]. |
==Reference== | ==Reference== | ||
Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A., Baker MD, Holloway DE, Swaminathan GJ, Acharya KR, Biochemistry. 2006 Jan 17;45(2):416-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16401072 16401072] | Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A., Baker MD, Holloway DE, Swaminathan GJ, Acharya KR, Biochemistry. 2006 Jan 17;45(2):416-26. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=16401072 16401072] | ||
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
| + | [[Category: Pancreatic ribonuclease]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Acharya, K.R.]] | [[Category: Acharya, K.R.]] | ||
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[[Category: sensory transduction]] | [[Category: sensory transduction]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:50:37 2007'' |
Revision as of 10:45, 30 October 2007
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CRYSTAL STRUCTURES OF EOSINOPHIL-DERIVED NEUROTOXIN IN COMPLEX WITH THE INHIBITORS 5'-ATP, AP3A, AP4A AND AP5A
Overview
Eosinophil-derived neurotoxin (EDN) is a catalytically proficient member, of the pancreatic ribonuclease superfamily secreted along with other, eosinophil granule proteins during innate host defense responses and, various eosinophil-related inflammatory and allergic diseases. The, ribonucleolytic activity of EDN is central to its antiviral and neurotoxic, activities and possibly to other facets of its biological activity. To, probe the importance of this enzymatic activity further, specific, inhibitors will be of great aid. Derivatives of 5'-ADP are among the most, potent inhibitors currently known. Here, we use X-ray crystallography to, investigate the binding of four natural nucleotides containing this, moiety. 5'-ATP binds in two alternative orientations, one occupying the B2, subsite ... [(full description)]
About this Structure
2C02 is a [Single protein] structure of sequence from [Homo sapiens] with ADP and ACY as [ligands]. Active as [Pancreatic ribonuclease], with EC number [3.1.27.5]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Crystal structures of eosinophil-derived neurotoxin (EDN) in complex with the inhibitors 5'-ATP, Ap3A, Ap4A, and Ap5A., Baker MD, Holloway DE, Swaminathan GJ, Acharya KR, Biochemistry. 2006 Jan 17;45(2):416-26. PMID:16401072
Page seeded by OCA on Tue Oct 30 12:50:37 2007
Categories: Homo sapiens | Pancreatic ribonuclease | Single protein | Acharya, K.R. | Baker, M.D. | Holloway, D.E. | Swaminathan, G.J. | ACY | ADP | 5'-atp | Ap3a | Ap4a | Ap5a | Chemotaxis | Endonuclease | Eosinophil | Glycoprotein | Hydrolase | Inhibitor | Nuclease | Polymorphism | Ribonuclease | Rnase us | Rnase-2 | Sensory transduction
