3r8i

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'''Unreleased structure'''
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[[Image:3r8i.png|left|200px]]
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The entry 3r8i is ON HOLD until Paper Publication
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{{STRUCTURE_3r8i| PDB=3r8i | SCENE= }}
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Authors: Pochetti, G., Montanari, R., Loiodice, F., Laghezza, A., Fracchiolla, G., Lavecchia, A., Novellino, E., Crestani, M.
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===Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86)===
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Description: Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86)
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{{ABSTRACT_PUBMED_22081932}}
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==About this Structure==
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[[3r8i]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R8I OCA].
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==Reference==
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<ref group="xtra">PMID:022081932</ref><ref group="xtra">PMID:017403688</ref><ref group="xtra">PMID:020462215</ref><references group="xtra"/>
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[[Category: Homo sapiens]]
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[[Category: Crestani, M.]]
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[[Category: Fracchiolla, G.]]
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[[Category: Laghezza, A.]]
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[[Category: Lavecchia, A.]]
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[[Category: Loiodice, F.]]
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[[Category: Montanari, R.]]
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[[Category: Novellino, E.]]
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[[Category: Pochetti, G.]]
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[[Category: Activator]]
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[[Category: Bundle of alpha-helice]]
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[[Category: Diabetes mellitus]]
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[[Category: Dna binding]]
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[[Category: Nucleus]]
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[[Category: Obesity]]
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[[Category: Phosphorylation]]
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[[Category: Protein-dna complex]]
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[[Category: Small four-stranded beta-sheet]]
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[[Category: Transcription]]
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[[Category: Transcription regulation]]

Revision as of 06:21, 11 January 2012

Image:3r8i.png

Template:STRUCTURE 3r8i

Crystal Structure of PPARgamma with an achiral ureidofibrate derivative (RT86)

Template:ABSTRACT PUBMED 22081932

About this Structure

3r8i is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Porcelli L, Gilardi F, Laghezza A, Piemontese L, Mitro N, Azzariti A, Altieri F, Cervoni L, Fracchiolla G, Giudici M, Guerrini U, Lavecchia A, Montanari R, Di Giovanni C, Paradiso A, Pochetti G, Simone GM, Tortorella P, Crestani M, Loiodice F. Synthesis, Characterization and Biological Evaluation of Ureidofibrate-Like Derivatives Endowed with Peroxisome Proliferator-Activated Receptor Activity. J Med Chem. 2011 Dec 2. PMID:22081932 doi:10.1021/jm201306q
  • Pochetti G, Godio C, Mitro N, Caruso D, Galmozzi A, Scurati S, Loiodice F, Fracchiolla G, Tortorella P, Laghezza A, Lavecchia A, Novellino E, Mazza F, Crestani M. Insights into the mechanism of partial agonism: crystal structures of the peroxisome proliferator-activated receptor gamma ligand-binding domain in the complex with two enantiomeric ligands. J Biol Chem. 2007 Jun 8;282(23):17314-24. Epub 2007 Apr 2. PMID:17403688 doi:10.1074/jbc.M702316200
  • Pochetti G, Mitro N, Lavecchia A, Gilardi F, Besker N, Scotti E, Aschi M, Re N, Fracchiolla G, Laghezza A, Tortorella P, Montanari R, Novellino E, Mazza F, Crestani M, Loiodice F. Structural insight into peroxisome proliferator-activated receptor gamma binding of two ureidofibrate-like enantiomers by molecular dynamics, cofactor interaction analysis, and site-directed mutagenesis. J Med Chem. 2010 Jun 10;53(11):4354-66. PMID:20462215 doi:10.1021/jm9013899

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