This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
O-GlcNAc transferase
From Proteopedia
| Line 2: | Line 2: | ||
| - | '''O-GlcNac transferase''' (OGT) catalyzes the addition of N-acetylglucosamine (GlcNAc) to serine or threonine residues by O-glycosylation. | + | '''O-GlcNac transferase''' (OGT) catalyzes the addition of N-acetylglucosamine (GlcNAc) to serine or threonine residues by O-glycosylation. For details see [[Human O-GlcNac transferase]]. |
{{TOC limit|limit=2}} | {{TOC limit|limit=2}} | ||
Revision as of 16:03, 13 January 2012
O-GlcNac transferase (OGT) catalyzes the addition of N-acetylglucosamine (GlcNAc) to serine or threonine residues by O-glycosylation. For details see Human O-GlcNac transferase.
3D structures of O-GlcNAc transferase
1fo8, 1fo9, 1foa - rOGT catalytic domain – rabbit
1w3b – hOGT TPR domain – human
2gak – mOGT – mouse
2j0a, 3otk – mOGT catalytic domain (mutant)
OGT binary complexes
2am3, 2am4 - rOGT catalytic domain + UDP-glucose derivative
2am5 - rOGT catalytic domain + UDP
2j0b - mOGT catalytic domain (mutant) + UDP
2apc - rOGT catalytic domain + UDP-GlcNAc phosphonate
2gam - mOGT + b-D-galactose + N-acetyl-galactosamine
3pe3, 3pe4 – hOGT residues 323-1041 + peptide substrate
2jlb – XcOGT + UDP-GlcNAc phosphonate analog – Xanthomonas campestris
2xgm – XcOGT + alloxan + mesoxalylurea
2xgc - XcOGT + UDP-GlcNAc
2xgs - XcOGT + UDP
1nlm – OGT + UDP-acetylglucosamine – Escherichia coli
3ee5 – hOGT + UDP + NAG + galactose + naphthalene derivative
