1gsz
From Proteopedia
(New page: 200px<br /> <applet load="1gsz" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gsz, resolution 2.8Å" /> '''CRYSTAL STRUCTURE OF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GSZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]] with C8E and R71 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GSZ OCA]]. | + | 1GSZ is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Alicyclobacillus_acidocaldarius Alicyclobacillus acidocaldarius]] with C8E and R71 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Structure known Active Site: C8A. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GSZ OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: oxidosqualene cyclase]] | [[Category: oxidosqualene cyclase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:51:49 2007'' |
Revision as of 10:47, 30 October 2007
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CRYSTAL STRUCTURE OF A SQUALENE CYCLASE IN COMPLEX WITH THE POTENTIAL ANTICHOLESTEREMIC DRUG RO48-8071
Overview
Squalene-hopene cyclase (SHC) catalyzes the conversion of squalene into, pentacyclic compounds. It is the prokaryotic counterpart of the eukaryotic, oxidosqualene cyclase (OSC) that catalyzes the steroid scaffold formation., Because of clear sequence homology, SHC can serve as a model for OSC, which is an attractive target for anticholesteremic drugs. We have, established the crystal structure of SHC complexed with Ro48-8071, a, potent inhibitor of OSC and therefore of cholesterol biosynthesis., Ro48-8071 is bound in the active-center cavity of SHC and extends into the, channel that connects the cavity with the membrane. The binding site of, Ro48-8071 is largely identical with the expected site of squalene; it, differs from a previous model based on photoaffinity labeling. The, knowledge ... [(full description)]
About this Structure
1GSZ is a [Single protein] structure of sequence from [Alicyclobacillus acidocaldarius] with C8E and R71 as [ligands]. Structure known Active Site: C8A. Full crystallographic information is available from [OCA].
Reference
Crystal structure of a squalene cyclase in complex with the potential anticholesteremic drug Ro48-8071., Lenhart A, Weihofen WA, Pleschke AE, Schulz GE, Chem Biol. 2002 May;9(5):639-45. PMID:12031670
Page seeded by OCA on Tue Oct 30 12:51:49 2007
