1gsy
From Proteopedia
(New page: 200px<br /> <applet load="1gsy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1gsy, resolution 2.44Å" /> '''GLUTATHIONE S-TRANS...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1GSY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with GTT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GSY OCA]]. | + | 1GSY is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]] with GTT as [[http://en.wikipedia.org/wiki/ligand ligand]]. Active as [[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18]]. Structure known Active Sites: GAS and GBS. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1GSY OCA]]. |
==Reference== | ==Reference== | ||
Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors., Garcia-Saez I, Parraga A, Phillips MF, Mantle TJ, Coll M, J Mol Biol. 1994 Apr 1;237(3):298-314. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8145243 8145243] | Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors., Garcia-Saez I, Parraga A, Phillips MF, Mantle TJ, Coll M, J Mol Biol. 1994 Apr 1;237(3):298-314. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8145243 8145243] | ||
| + | [[Category: Glutathione transferase]] | ||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: transferase]] | [[Category: transferase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:52:01 2007'' |
Revision as of 10:47, 30 October 2007
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GLUTATHIONE S-TRANSFERASE YFYF, CLASS PI, COMPLEXED WITH GLUTATHIONE
Overview
The three-dimensional crystal structure of pi class glutathione, S-transferase YfYf from mouse liver complexed with the inhibitor, S-(p-nitrobenzyl)glutathione has been determined at 1.8 A resolution by, X-ray diffraction. In addition two complexes with glutathione sulphonic, acid and S-hexylglutathione have been determined at resolutions of 1.9 and, 2.2 A, respectively. The high resolution of the, S-(p-nitrobenzyl)glutathione complex allows a detailed analysis of the, active site including the hydrophobic (H-) subsite. The nitrobenzyl moiety, occupies a hydrophobic pocket with its aromatic ring sandwiched between, Phe8 and the hydroxyl group of Tyr108. An insertion of two residues Gly41, and Leu42, with respect to the pig enzyme, splits helix alpha B into an, alpha-helix and a 3(10) ... [(full description)]
About this Structure
1GSY is a [Single protein] structure of sequence from [Mus musculus] with GTT as [ligand]. Active as [Glutathione transferase], with EC number [2.5.1.18]. Structure known Active Sites: GAS and GBS. Full crystallographic information is available from [OCA].
Reference
Molecular structure at 1.8 A of mouse liver class pi glutathione S-transferase complexed with S-(p-nitrobenzyl)glutathione and other inhibitors., Garcia-Saez I, Parraga A, Phillips MF, Mantle TJ, Coll M, J Mol Biol. 1994 Apr 1;237(3):298-314. PMID:8145243
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