4a2z

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'''Unreleased structure'''
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[[Image:4a2z.png|left|200px]]
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The entry 4a2z is ON HOLD
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{{STRUCTURE_4a2z| PDB=4a2z | SCENE= }}
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Authors: Robinson, D.A., Brand, S., Fairlamb, A.H., Ferguson, M.A.J., Frearson, J.A., Wyatt, P.G.
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===CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND===
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Description: CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
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{{ABSTRACT_PUBMED_22148754}}
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==About this Structure==
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[[4a2z]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Leishmania_major Leishmania major]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A2Z OCA].
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==Reference==
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<ref group="xtra">PMID:022148754</ref><ref group="xtra">PMID:020360736</ref><references group="xtra"/>
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[[Category: Glycylpeptide N-tetradecanoyltransferase]]
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[[Category: Leishmania major]]
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[[Category: Brand, S.]]
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[[Category: Fairlamb, A H.]]
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[[Category: Ferguson, M A.J.]]
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[[Category: Frearson, J A.]]
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[[Category: Robinson, D A.]]
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[[Category: Wyatt, P G.]]
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[[Category: Acyltransferase]]
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[[Category: Drug discovery]]
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[[Category: Transferase]]

Revision as of 05:35, 25 January 2012

Image:4a2z.png

Template:STRUCTURE 4a2z

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND

Template:ABSTRACT PUBMED 22148754

About this Structure

4a2z is a 1 chain structure with sequence from Leishmania major. Full crystallographic information is available from OCA.

Reference

  • Brand S, Cleghorn LA, McElroy SP, Robinson DA, Smith VC, Hallyburton I, Harrison JR, Norcross NR, Spinks D, Bayliss T, Norval S, Stojanovski L, Torrie LS, Frearson JA, Brenk R, Fairlamb AH, Ferguson MA, Read KD, Wyatt PG, Gilbert IH. Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J Med Chem. 2012 Jan 12;55(1):140-52. Epub 2011 Dec 7. PMID:22148754 doi:10.1021/jm201091t
  • Frearson JA, Brand S, McElroy SP, Cleghorn LA, Smid O, Stojanovski L, Price HP, Guther ML, Torrie LS, Robinson DA, Hallyburton I, Mpamhanga CP, Brannigan JA, Wilkinson AJ, Hodgkinson M, Hui R, Qiu W, Raimi OG, van Aalten DM, Brenk R, Gilbert IH, Read KD, Fairlamb AH, Ferguson MA, Smith DF, Wyatt PG. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature. 2010 Apr 1;464(7289):728-32. PMID:20360736 doi:10.1038/nature08893

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