4rhn
From Proteopedia
(New page: 200px<br /> <applet load="4rhn" size="450" color="white" frame="true" align="right" spinBox="true" caption="4rhn, resolution 1.90Å" /> '''HISTIDINE TRIAD NUC...) |
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==About this Structure== | ==About this Structure== | ||
| - | 4RHN is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]] with RIB as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4RHN OCA]]. | + | 4RHN is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]] with RIB as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: HIT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=4RHN OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: nucleotide-binding protein]] | [[Category: nucleotide-binding protein]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:52:11 2007'' |
Revision as of 10:47, 30 October 2007
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HISTIDINE TRIAD NUCLEOTIDE-BINDING PROTEIN (HINT) FROM RABBIT COMPLEXED WITH ADENOSINE
Overview
Histidine triad nucleotide-binding protein (HINT), a dimeric purine, nucleotide-binding protein from rabbit heart, is a member of the HIT, (histidine triad) superfamily which includes HINT homologues and FHIT (HIT, protein encoded at the chromosome 3 fragile site) homologues. Crystal, structures of HINT-nucleotide complexes demonstrate that the most, conserved residues in the superfamily mediate nucleotide binding and that, the HIT motif forms part of the phosphate binding loop., Galactose-1-phosphate uridylyltransferase, whose deficiency causes, galactosemia, contains tandem HINT domains with the same fold and mode of, nucleotide binding as HINT despite having no overall sequence similarity., Features of FHIT, a diadenosine polyphosphate hydrolase and candidate, tumour suppressor, are ... [(full description)]
About this Structure
4RHN is a [Single protein] structure of sequence from [Oryctolagus cuniculus] with RIB as [ligand]. Structure known Active Site: HIT. Full crystallographic information is available from [OCA].
Reference
Crystal structures of HINT demonstrate that histidine triad proteins are GalT-related nucleotide-binding proteins., Brenner C, Garrison P, Gilmour J, Peisach D, Ringe D, Petsko GA, Lowenstein JM, Nat Struct Biol. 1997 Mar;4(3):231-8. PMID:9164465
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