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3thb

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Revision as of 05:47, 25 January 2012

Image:3thb.png

Template:STRUCTURE 3thb

Structure of PLK1 kinase domain in complex with a benzolactam-derived inhibitor

Template:ABSTRACT PUBMED 22070629

About this Structure

3thb is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Duffey MO, Vos TJ, Adams R, Alley J, Anthony J, Barrett C, Bharathan I, Bowman D, Bump NJ, Chau R, Cullis C, Driscoll DL, Elder A, Forsyth N, Frazer J, Guo J, Guo L, Hyer ML, Janowick D, Kulkarni B, Lai SJ, Lasky K, Li G, Li J, Liao D, Little J, Peng B, Qian MG, Reynolds DJ, Rezaei M, Scott MP, Sells TB, Shinde V, Shi QJ, Sintchak MD, Soucy F, Sprott KT, Stroud SG, Nestor M, Visieres I, Weatherhead G, Ye Y, D'Amore N. Discovery of a Potent and Orally Bioavailable Benzolactam-Derived Inhibitor of Polo-Like Kinase 1 (MLN0905). J Med Chem. 2011 Nov 9. PMID:22070629 doi:10.1021/jm2011172

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OCA

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