3e64
From Proteopedia
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[[Image:3e64.png|left|200px]] | [[Image:3e64.png|left|200px]] | ||
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{{ABSTRACT_PUBMED_19019674}} | {{ABSTRACT_PUBMED_19019674}} | ||
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| - | ==Disease== | ||
| - | Known disease associated with this structure: Leukemia, acute myelogenous OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myelofibrosis, idiopathic OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Myeloproliferative disorder with erythrocytosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Polycythemia vera OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Thrombocythemia, essential OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]], Budd-Chiari syndrome OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=147796 147796]] | ||
==About this Structure== | ==About this Structure== | ||
| - | + | [[3e64]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3E64 OCA]. | |
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019019674</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Non-specific protein-tyrosine kinase]] | [[Category: Non-specific protein-tyrosine kinase]] | ||
[[Category: Antonysamy, S S.]] | [[Category: Antonysamy, S S.]] | ||
[[Category: Atp-binding]] | [[Category: Atp-binding]] | ||
| - | [[Category: Chromosomal rearrangement]] | ||
[[Category: Disease mutation]] | [[Category: Disease mutation]] | ||
[[Category: Drug discovery]] | [[Category: Drug discovery]] | ||
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[[Category: Nucleotide-binding]] | [[Category: Nucleotide-binding]] | ||
[[Category: Phosphoprotein]] | [[Category: Phosphoprotein]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Proto-oncogene]] | [[Category: Proto-oncogene]] | ||
[[Category: Sh2 domain]] | [[Category: Sh2 domain]] | ||
[[Category: Transferase]] | [[Category: Transferase]] | ||
[[Category: Tyrosine-protein kinase]] | [[Category: Tyrosine-protein kinase]] | ||
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Feb 17 09:18:34 2009'' | ||
Revision as of 06:35, 1 February 2012
Fragment based discovery of JAK-2 inhibitors
Template:ABSTRACT PUBMED 19019674
About this Structure
3e64 is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Antonysamy S, Hirst G, Park F, Sprengeler P, Stappenbeck F, Steensma R, Wilson M, Wong M. Fragment-based discovery of JAK-2 inhibitors. Bioorg Med Chem Lett. 2009 Jan 1;19(1):279-82. Epub 2008 Aug 22. PMID:19019674 doi:10.1016/j.bmcl.2008.08.064
