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3r6t

From Proteopedia

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'''Unreleased structure'''
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[[Image:3r6t.png|left|200px]]
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The entry 3r6t is ON HOLD until Paper Publication
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{{STRUCTURE_3r6t| PDB=3r6t | SCENE= }}
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Authors: Ehler, A., Schlatter, D., Stihle, M., Benz, J., Rudolph, M.G.
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===Rat catechol o-methyltransferase in complex with the bisubstrate inhibitor 4'-fluoro-4,5-dihydroxy-biphenyl-3-carboxylic acid {(E)-3-[(2S,4R,5R)-4-hydroxy-5-(6-methyl-purin-9-yl)-tetrahydro-furan-2-yl]-allyl}-amide===
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Description: Rat catechol o-methyltransferase in complex with the bisubstrate inhibitor 4'-fluoro-4,5-dihydroxy-biphenyl-3-carboxylic acid {(E)-3-[(2S,4R,5R)-4-hydroxy-5-(6-methyl-purin-9-yl)-tetrahydro-furan-2-yl]-allyl}-amide
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{{ABSTRACT_PUBMED_21538606}}
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==About this Structure==
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[[3r6t]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3R6T OCA].
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==Reference==
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<ref group="xtra">PMID:021538606</ref><references group="xtra"/>
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[[Category: Catechol O-methyltransferase]]
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[[Category: Rattus norvegicus]]
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[[Category: Benz, J.]]
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[[Category: Ehler, A.]]
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[[Category: Rudolph, M G.]]
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[[Category: Schlatter, D.]]
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[[Category: Stihle, M.]]
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[[Category: Alternative initiation]]
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[[Category: Catecholamine metabolism]]
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[[Category: Metal-binding]]
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[[Category: Methyltransferase]]
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[[Category: Neurotransmitter degradation]]
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[[Category: S-adenosyl-l-methionine]]
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[[Category: Transferase-transferase inhibitor complex]]
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[[Category: Transmembrane]]

Revision as of 05:38, 8 February 2012

Image:3r6t.png

Template:STRUCTURE 3r6t

Rat catechol o-methyltransferase in complex with the bisubstrate inhibitor 4'-fluoro-4,5-dihydroxy-biphenyl-3-carboxylic acid {(E)-3-[(2S,4R,5R)-4-hydroxy-5-(6-methyl-purin-9-yl)-tetrahydro-furan-2-yl]-allyl}-amide

Template:ABSTRACT PUBMED 21538606

About this Structure

3r6t is a 1 chain structure with sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

  • Ellermann M, Paulini R, Jakob-Roetne R, Lerner C, Borroni E, Roth D, Ehler A, Schweizer WB, Schlatter D, Rudolph MG, Diederich F. Molecular Recognition at the Active Site of Catechol-O-methyltransferase (COMT): Adenine Replacements in Bisubstrate Inhibitors. Chemistry. 2011 May 27;17(23):6369-81. doi: 10.1002/chem.201003648. Epub, 2011 Apr 27. PMID:21538606 doi:10.1002/chem.201003648

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