2p1y
From Proteopedia
(New page: 200px<br /><applet load="2p1y" size="350" color="white" frame="true" align="right" spinBox="true" caption="2p1y" /> ''''''<br /> ==About this Structure== is a [h...) |
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[[Image:2p1y.jpg|left|200px]]<br /><applet load="2p1y" size="350" color="white" frame="true" align="right" spinBox="true" | [[Image:2p1y.jpg|left|200px]]<br /><applet load="2p1y" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2p1y" /> | + | caption="2p1y, resolution 2.42Å" /> |
| - | ''''''<br /> | + | '''1.B2.D9, a bispecific alpha/beta TCR'''<br /> |
| + | |||
| + | ==Overview== | ||
| + | We report crystal structures of a negatively selected T cell receptor, (TCR) that recognizes two I-A(u)-restricted myelin basic protein peptides, and one of its peptide/major histocompatibility complex (pMHC) ligands., Unusual complementarity-determining region (CDR) structural features, revealed by our analyses identify a previously unrecognized mechanism by, which the highly variable CDR3 regions define ligand specificity. In, addition to the pMHC contact residues contributed by CDR3, the CDR3, residues buried deep within the V alpha/V beta interface exert indirect, effects on recognition by influencing the V alpha/V beta interdomain, angle. This phenomenon represents an additional mechanism for increasing, the potential diversity of the TCR repertoire. Both the direct and, indirect effects exerted by CDR residues can impact global TCR/MHC, docking. Analysis of the available TCR structures in light of these, results highlights the significance of the V alpha/V beta interdomain, angle in determining specificity and indicates that TCR/pMHC interface, features do not distinguish autoimmune from non-autoimmune class, II-restricted TCRs. | ||
==About this Structure== | ==About this Structure== | ||
| - | + | 2P1Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P1Y OCA]. | |
| - | [[Category: | + | |
| + | ==Reference== | ||
| + | A new twist in TCR diversity revealed by a forbidden alphabeta TCR., McBeth C, Seamons A, Pizarro JC, Fleishman SJ, Baker D, Kortemme T, Goverman JM, Strong RK, J Mol Biol. 2008 Feb 1;375(5):1306-19. Epub 2007 Nov 17. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=18155234 18155234] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Single protein]] | ||
| + | [[Category: McBeth, C.]] | ||
| + | [[Category: Pizarro, J.C.]] | ||
| + | [[Category: Strong, R.K.]] | ||
| + | [[Category: autoimmunity]] | ||
| + | [[Category: diabody]] | ||
| + | [[Category: immune system]] | ||
| + | [[Category: immunoglobulin fold]] | ||
| + | [[Category: tcr]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 6 | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 6 17:23:06 2008'' |
Revision as of 15:23, 6 February 2008
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1.B2.D9, a bispecific alpha/beta TCR
Overview
We report crystal structures of a negatively selected T cell receptor, (TCR) that recognizes two I-A(u)-restricted myelin basic protein peptides, and one of its peptide/major histocompatibility complex (pMHC) ligands., Unusual complementarity-determining region (CDR) structural features, revealed by our analyses identify a previously unrecognized mechanism by, which the highly variable CDR3 regions define ligand specificity. In, addition to the pMHC contact residues contributed by CDR3, the CDR3, residues buried deep within the V alpha/V beta interface exert indirect, effects on recognition by influencing the V alpha/V beta interdomain, angle. This phenomenon represents an additional mechanism for increasing, the potential diversity of the TCR repertoire. Both the direct and, indirect effects exerted by CDR residues can impact global TCR/MHC, docking. Analysis of the available TCR structures in light of these, results highlights the significance of the V alpha/V beta interdomain, angle in determining specificity and indicates that TCR/pMHC interface, features do not distinguish autoimmune from non-autoimmune class, II-restricted TCRs.
About this Structure
2P1Y is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
A new twist in TCR diversity revealed by a forbidden alphabeta TCR., McBeth C, Seamons A, Pizarro JC, Fleishman SJ, Baker D, Kortemme T, Goverman JM, Strong RK, J Mol Biol. 2008 Feb 1;375(5):1306-19. Epub 2007 Nov 17. PMID:18155234
Page seeded by OCA on Wed Feb 6 17:23:06 2008
