Plectin
From Proteopedia
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| - | Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3). | + | '''Plectin''', a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure <ref>PMID:3430617</ref>. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3). |
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| + | ==3D structures of plectin== | ||
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| + | [[1mb8]] – hPCN actin-binding domain – human | ||
| + | [[1sh5]], [[1sh6]] - PCN actin-binding domain – mouse | ||
| + | [[3pdy]], [[3pe0]] - hPCN plakin domain | ||
| + | [[2odu]], [[2odv]] – hPCN plakin domain (mutant) | ||
| + | [[3f7p]] - hPCN actin-binding domain + integrin β4 residues 1126-1370 | ||
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<references/> | <references/> | ||
Revision as of 07:13, 8 February 2012
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Plectin, a universal and functionally versatile cytolinker protein, can be divided in three main sections; a central coiled-coil rod domain, N and C-terminal globular region and exhibits a dumbbell like structure [1]. C-terminal region is composed of 6 homologous repeating domains, and this region has a role in binding to intermediate filaments such as vimentin and cytokeratin (2). N-terminal globular region contains actin binding domain (ABD) comprising two calponin homology (CH) domains and N-terminal arm, which varies among isoforms (3).
3D structures of plectin
1mb8 – hPCN actin-binding domain – human 1sh5, 1sh6 - PCN actin-binding domain – mouse 3pdy, 3pe0 - hPCN plakin domain 2odu, 2odv – hPCN plakin domain (mutant) 3f7p - hPCN actin-binding domain + integrin β4 residues 1126-1370
- ↑ Foisner R, Wiche G. Structure and hydrodynamic properties of plectin molecules. J Mol Biol. 1987 Dec 5;198(3):515-31. PMID:3430617
