Response regulator
From Proteopedia
| Line 13: | Line 13: | ||
===Nitrate/nitrite RR=== | ===Nitrate/nitrite RR=== | ||
| - | [[1rnl]], [[1a04]] – EcNarL – Escherichia coli<br/ > | + | [[1rnl]], [[1a04]] – EcNarL – ''Escherichia coli''<br/ > |
[[1je8]], [[1zg1]], [[1zg5]] – EcNarL DNA-binding domain + DNA | [[1je8]], [[1zg1]], [[1zg5]] – EcNarL DNA-binding domain + DNA | ||
===Sporulation RR=== | ===Sporulation RR=== | ||
| - | [[1srr]] – BsSpo0F (mutant) – Bacillus subtilis<br/ > | + | [[1srr]] – BsSpo0F (mutant) – ''Bacillus subtilis''<br/ > |
[[1nat]] - BsSpo0F<br/ > | [[1nat]] - BsSpo0F<br/ > | ||
[[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ > | [[3q15]] - BsSpo0F + RR aspartate phosphatase<br/ > | ||
[[1ixm]] - BsSpo0B<br/ > | [[1ixm]] - BsSpo0B<br/ > | ||
| - | [[1fc3]] – Spo0A trans-activation domain – Geobacillus stearothermophilus | + | [[1fc3]] – Spo0A trans-activation domain – ''Geobacillus stearothermophilus'' |
===DNA-binding RR=== | ===DNA-binding RR=== | ||
| - | [[1kgs]] – TmDrrD – Thermotoga maritima<br/ > | + | [[1kgs]] – TmDrrD – ''Thermotoga maritima''<br/ > |
[[3nnn]] – TmDrrD receiver domain + BeF3<BR/ > | [[3nnn]] – TmDrrD receiver domain + BeF3<BR/ > | ||
[[1p2f]] – TmDrrB<br/ > | [[1p2f]] – TmDrrB<br/ > | ||
[[3nns]] - TmDrrB receiver domain + BeF3<BR/ > | [[3nns]] - TmDrrB receiver domain + BeF3<BR/ > | ||
| - | [[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpMicArec receiver domain – Streptococcus pneumonia<br/ > | + | [[1nxo]], [[1nxp]], [[1nxs]], [[1nxt]], [[1nxv]], [[1nxw]], [[1nxx]] – SpMicArec receiver domain – ''Streptococcus pneumonia''<br/ > |
| - | [[2gwr]] - MtMtrA – Mycobacterium tuberculosis<br/ > | + | [[2gwr]] - MtMtrA – ''Mycobacterium tuberculosis''<br/ > |
| - | [[2hwv]] – VicR C terminal – Enterococcus faecalis<br/ > | + | [[2hwv]] – VicR C terminal – ''Enterococcus faecalis''<br/ > |
| - | [[2qsj]] – LuxR – Silicibbacter pomeroyi<br/ > | + | [[2qsj]] – LuxR – ''Silicibbacter pomeroyi''<br/ > |
| - | [[3cnb]], 3eqz]] – MerR receiver domain – Colwellia psychrerythraea<br/ > | + | [[3cnb]], 3eqz]] – MerR receiver domain – ''Colwellia psychrerythraea''<br/ > |
| - | [[2rnj]] – SaVraR DNA-binding domain – Staphylococcus aureus – NMR<br/ > | + | [[2rnj]] – SaVraR DNA-binding domain – ''Staphylococcus aureus'' – NMR<br/ > |
[[2zxj]] - SaWalR DNA-binding domain<br/ > | [[2zxj]] - SaWalR DNA-binding domain<br/ > | ||
| - | [[3q9s]] – DrRR receiver domain – Deinococcus radiodurans<br/ > | + | [[3q9s]] – DrRR receiver domain – ''Deinococcus radiodurans''<br/ > |
[[3q9v]] - DrRR C terminal | [[3q9v]] - DrRR C terminal | ||
| Line 43: | Line 43: | ||
===Cyanobacterial phytochrome RR=== | ===Cyanobacterial phytochrome RR=== | ||
| - | [[1i3c]] – SyRcp1 – Synechocystis<br/ > | + | [[1i3c]] – SyRcp1 – ''Synechocystis''<br/ > |
[[1jlk]] – SyRcp1 + Mn<br/ > | [[1jlk]] – SyRcp1 + Mn<br/ > | ||
| - | [[1k66]] – ToRcpB – Tolypothrix<br/ > | + | [[1k66]] – ToRcpB – ''Tolypothrix''<br/ > |
[[1k68]] – ToRcpB | [[1k68]] – ToRcpB | ||
| Line 56: | Line 56: | ||
===Polar differentiation RR=== | ===Polar differentiation RR=== | ||
| - | [[1m5t]], [[1m5u]] – CvDivK – Caulobacter vibrioides<br/ > | + | [[1m5t]], [[1m5u]] – CvDivK – ''Caulobacter vibrioides''<br/ > |
[[1mav]], [[1mb0]], [[1mb3]] – CvDivK + cation | [[1mav]], [[1mb0]], [[1mb3]] – CvDivK + cation | ||
===Photosynthetic apparatus RR=== | ===Photosynthetic apparatus RR=== | ||
| - | [[1umq]] – PrrA DNA-binding domain – Rhodobacter sphaeroides – NMR<br/ > | + | [[1umq]] – PrrA DNA-binding domain – ''Rhodobacter sphaeroides'' – NMR<br/ > |
[[1ys6]] – MtPrrA <br/ > | [[1ys6]] – MtPrrA <br/ > | ||
[[1ys7]] – MtPrrA + Mg | [[1ys7]] – MtPrrA + Mg | ||
| Line 72: | Line 72: | ||
===Social motility RR=== | ===Social motility RR=== | ||
| - | [[2gkg]], [[2i6f]] – MxFrzS receiver domain – Myxococcus xanthus <br/ > | + | [[2gkg]], [[2i6f]] – MxFrzS receiver domain – ''Myxococcus xanthus'' <br/ > |
[[2nt3]], [[2nt4]] - MxFrzS receiver domain (mutant) | [[2nt3]], [[2nt4]] - MxFrzS receiver domain (mutant) | ||
| Line 96: | Line 96: | ||
===CheY-like RR=== | ===CheY-like RR=== | ||
| - | [[3snk]] – RR – Mesorhizobium loti<br/ > | + | [[3snk]] – RR – ''Mesorhizobium loti''<br/ > |
| - | [[3cg4]], [[3crn]] - RR receiver domain – Methanospirillum hungatei<br/ > | + | [[3cg4]], [[3crn]] - RR receiver domain – ''Methanospirillum hungatei''<br/ > |
| - | [[3i42]] – RR receiver domain – Methylobacter flagellates | + | [[3i42]] – RR receiver domain – ''Methylobacter flagellates'' |
===Unspecified RR receiver domain=== | ===Unspecified RR receiver domain=== | ||
| Line 104: | Line 104: | ||
[[2a9o]], [[2a9p]], [[2a9q]] – SpRR + Mn + BeF3<BR/ > | [[2a9o]], [[2a9p]], [[2a9q]] – SpRR + Mn + BeF3<BR/ > | ||
[[2a9r]] – SpRR + phosphate + Mg<br/ > | [[2a9r]] – SpRR + phosphate + Mg<br/ > | ||
| - | [[2pln]] – HP1043 – Helicobacter pylori<br/ > | + | [[2pln]] – HP1043 – ''Helicobacter pylori''<br/ > |
| - | [[2qr3]] – RR – Bacteroides fragilis<br/ > | + | [[2qr3]] – RR – ''Bacteroides fragilis''<br/ > |
[[2qxy]] – TmRR <br/ > | [[2qxy]] – TmRR <br/ > | ||
| - | [[2qzj]] – RR – Clostridium difficile<br/ > | + | [[2qzj]] – RR – ''Clostridium difficile''<br/ > |
| - | [[3kht]] – RR – Hahella chejuensis<br/ > | + | [[3kht]] – RR – ''Hahella chejuensis''<br/ > |
| - | [[3c3m]] – RR – Methanoculleus marisnigri<br/ > | + | [[3c3m]] – RR – ''Methanoculleus marisnigri''<br/ > |
| - | [[3cz5]] – RR – Aurantimonas<br/ > | + | [[3cz5]] – RR – ''Aurantimonas''<br/ > |
| - | [[3heb]] - RR – Rhodospirillum rubrum<br/ > | + | [[3heb]] - RR – ''Rhodospirillum rubrum''<br/ > |
| - | [[3lte]] – RR – Bermanella marisrubri<br/ > | + | [[3lte]] – RR – ''Bermanella marisrubri''<br/ > |
| - | [[3jte]], [[3lua]] – RR – Clostridium thermocellum | + | [[3jte]], [[3lua]] – RR – ''Clostridium thermocellum'' |
===Unspecified RR=== | ===Unspecified RR=== | ||
| - | [[1yio]], [[1zn2]] – StyR – Pseudomonas fluorescens<br/ > | + | [[1yio]], [[1zn2]] – StyR – ''Pseudomonas fluorescens''<br/ > |
[[3a0u]], [[3a10]] – TmTrrA + Mg + BeF3<BR/ > | [[3a0u]], [[3a10]] – TmTrrA + Mg + BeF3<BR/ > | ||
| - | [[2qvg]] – RR – Legionella pneumophila<br/ > | + | [[2qvg]] – RR – ''Legionella pneumophila''<br/ > |
[[3gl9]] - TmRR<br/ > | [[3gl9]] - TmRR<br/ > | ||
| - | [[2zay]] – RR – Desulfuromonas acetoxidans<br/ > | + | [[2zay]] – RR – ''Desulfuromonas acetoxidans''<br/ > |
| - | [[2rdm]] – RR (mutant) – Sinorhizobium medicae<br/ > | + | [[2rdm]] – RR (mutant) – ''Sinorhizobium medicae''<br/ > |
| - | [[3bre]] – PaRR – Pseudomonas aeruginosa<br/ > | + | [[3bre]] – PaRR – ''Pseudomonas aeruginosa''<br/ > |
| - | [[3hdv]] – RR – Pseudomonas putida<br/ > | + | [[3hdv]] – RR – ''Pseudomonas putida''<br/ > |
| - | [[3i5a]] – PsWspR – Pseudomonas syringae<br/ > | + | [[3i5a]] – PsWspR – ''Pseudomonas syringae''<br/ > |
| - | [[3ilh]] – RR – Cytophaga hutchinsonii<br/ > | + | [[3ilh]] – RR – ''Cytophaga hutchinsonii''<br/ > |
[[3i5b]] – PaWspR GGDEF domain<br/ > | [[3i5b]] – PaWspR GGDEF domain<br/ > | ||
[[3i5c]] – PaWspR GGDEF domain/GCN4 leucine zipper<br/ > | [[3i5c]] – PaWspR GGDEF domain/GCN4 leucine zipper<br/ > | ||
| - | [[3ljx]] – McMmoQ – Methylococcus capsulatus<br/ > | + | [[3ljx]] – McMmoQ – ''Methylococcus capsulatus''<br/ > |
[[3p3q]] – McMmoQ (mutant) <br/ > | [[3p3q]] – McMmoQ (mutant) <br/ > | ||
| - | [[3lsg]] – RR C terminal – Fusobacterium nucleatum<br/ > | + | [[3lsg]] – RR C terminal – ''Fusobacterium nucleatum''<br/ > |
[[3nhm]] – MxRR<br/ > | [[3nhm]] – MxRR<br/ > | ||
| - | [[3m6m]] – XcRpfC REC domain + enoyl-CoA hydratase – Xanthomonas campestris<br/ > | + | [[3m6m]] – XcRpfC REC domain + enoyl-CoA hydratase – ''Xanthomonas campestris''<br/ > |
[[3qyy]] – XcRR GGDEF domain + GMP<br/ > | [[3qyy]] – XcRR GGDEF domain + GMP<br/ > | ||
| - | [[3p01]] – RR residues 134-315 – Nostoc<br/ > | + | [[3p01]] – RR residues 134-315 – ''Nostoc''<br/ > |
| - | [[3rqi]] – RR + phosphate + Ca + citrate – Burkholderia pseudomallei<br/ > | + | [[3rqi]] – RR + phosphate + Ca + citrate – ''Burkholderia pseudomallei''<br/ > |
| - | [[3kto]] – RR - Pseudoalteromonas atlantica | + | [[3kto]] – RR - ''Pseudoalteromonas atlantica'' |
===RR complex with histidine kinase=== | ===RR complex with histidine kinase=== | ||
Revision as of 08:10, 9 February 2012
Response regulators (RR) are part of the two-component signal transduction systems which enable bacteria to sense and respond to a wide range of environments. Two-component RR is a complex of histidine kinase (sensor protein SP) and RR. The RR act as phosphorylation-activated switches. Most RR consist of N terminal shich is the signal receiving domain and C terminal which is the DNA-binding domain. RR CheY is a chemotaxis response regulator in bacteria. RR Spo0 is the sporulation response regulator. Details on response regulator PleD see PleD activation, PleD allosteric product inhibition, PleD catalysis. For details on PhoP see PhoP Regulatory Domain and PhoP-PhoQ.
3D Structures of response regulator
Updated December 2011
Nitrate/nitrite RR
1rnl, 1a04 – EcNarL – Escherichia coli
1je8, 1zg1, 1zg5 – EcNarL DNA-binding domain + DNA
Sporulation RR
1srr – BsSpo0F (mutant) – Bacillus subtilis
1nat - BsSpo0F
3q15 - BsSpo0F + RR aspartate phosphatase
1ixm - BsSpo0B
1fc3 – Spo0A trans-activation domain – Geobacillus stearothermophilus
DNA-binding RR
1kgs – TmDrrD – Thermotoga maritima
3nnn – TmDrrD receiver domain + BeF3
1p2f – TmDrrB
3nns - TmDrrB receiver domain + BeF3
1nxo, 1nxp, 1nxs, 1nxt, 1nxv, 1nxw, 1nxx – SpMicArec receiver domain – Streptococcus pneumonia
2gwr - MtMtrA – Mycobacterium tuberculosis
2hwv – VicR C terminal – Enterococcus faecalis
2qsj – LuxR – Silicibbacter pomeroyi
3cnb, 3eqz]] – MerR receiver domain – Colwellia psychrerythraea
2rnj – SaVraR DNA-binding domain – Staphylococcus aureus – NMR
2zxj - SaWalR DNA-binding domain
3q9s – DrRR receiver domain – Deinococcus radiodurans
3q9v - DrRR C terminal
Cyanobacterial phytochrome RR
1i3c – SyRcp1 – Synechocystis
1jlk – SyRcp1 + Mn
1k66 – ToRcpB – Tolypothrix
1k68 – ToRcpB
Phosphatase synthesis RR
1mvo – BsPhoP receiver domain
2jb9, 2jba – EcPhoB (mutant)
2pmu – MtPhoP DNA-binding domain
Polar differentiation RR
1m5t, 1m5u – CvDivK – Caulobacter vibrioides
1mav, 1mb0, 1mb3 – CvDivK + cation
Photosynthetic apparatus RR
1umq – PrrA DNA-binding domain – Rhodobacter sphaeroides – NMR
1ys6 – MtPrrA
1ys7 – MtPrrA + Mg
Redox RR
1xhe – EcArcA receiver domain
1xhf – EcArcA receiver domain + BeF3
Social motility RR
2gkg, 2i6f – MxFrzS receiver domain – Myxococcus xanthus
2nt3, 2nt4 - MxFrzS receiver domain (mutant)
Stalked-cell differentiation RR
2v0n – CvPleD + GMP + GTP
2wb4, 1w25]] - CvPleD + GMP
Hypoxic RR
3c3w – MtDosR
3c57 – MtDosR C terminal
Transcriptional RR
2zwm – BsYycF receiver domain
3ulq – BsComA DNA-binding domain + RR aspartate phosphatase
Stress RR
3n0r – CVPhyR
CheY-like RR
3snk – RR – Mesorhizobium loti
3cg4, 3crn - RR receiver domain – Methanospirillum hungatei
3i42 – RR receiver domain – Methylobacter flagellates
Unspecified RR receiver domain
2a9o, 2a9p, 2a9q – SpRR + Mn + BeF3
2a9r – SpRR + phosphate + Mg
2pln – HP1043 – Helicobacter pylori
2qr3 – RR – Bacteroides fragilis
2qxy – TmRR
2qzj – RR – Clostridium difficile
3kht – RR – Hahella chejuensis
3c3m – RR – Methanoculleus marisnigri
3cz5 – RR – Aurantimonas
3heb - RR – Rhodospirillum rubrum
3lte – RR – Bermanella marisrubri
3jte, 3lua – RR – Clostridium thermocellum
Unspecified RR
1yio, 1zn2 – StyR – Pseudomonas fluorescens
3a0u, 3a10 – TmTrrA + Mg + BeF3
2qvg – RR – Legionella pneumophila
3gl9 - TmRR
2zay – RR – Desulfuromonas acetoxidans
2rdm – RR (mutant) – Sinorhizobium medicae
3bre – PaRR – Pseudomonas aeruginosa
3hdv – RR – Pseudomonas putida
3i5a – PsWspR – Pseudomonas syringae
3ilh – RR – Cytophaga hutchinsonii
3i5b – PaWspR GGDEF domain
3i5c – PaWspR GGDEF domain/GCN4 leucine zipper
3ljx – McMmoQ – Methylococcus capsulatus
3p3q – McMmoQ (mutant)
3lsg – RR C terminal – Fusobacterium nucleatum
3nhm – MxRR
3m6m – XcRpfC REC domain + enoyl-CoA hydratase – Xanthomonas campestris
3qyy – XcRR GGDEF domain + GMP
3p01 – RR residues 134-315 – Nostoc
3rqi – RR + phosphate + Ca + citrate – Burkholderia pseudomallei
3kto – RR - Pseudoalteromonas atlantica
RR complex with histidine kinase
3dge, 3dgf]] – TmRR + sensor protein
3a0r – TmTrrA (mutant) + sensor protein
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Joel L. Sussman, Alexander Berchansky, Jaime Prilusky
