Proto-oncogene tyrosine-protein kinase
From Proteopedia
| Line 18: | Line 18: | ||
[[1yi6]] – hNTPK SRC C terminal - human<br /> | [[1yi6]] – hNTPK SRC C terminal - human<br /> | ||
[[1yoj]] - hNTPK SRC kinase domain (mutant) <br /> | [[1yoj]] - hNTPK SRC kinase domain (mutant) <br /> | ||
| - | [[1fmk]] - hNTPK SRC kinase, SH2, SH3, C terminal domains | + | [[1fmk]] - hNTPK SRC kinase, SH2, SH3, C terminal domains<br /> |
| + | [[1k9a]] – CSK – rat<br /> | ||
| + | [[3eac]] – hCSK SH2 domain<br /> | ||
| + | [[3eaz]] – hCSK SH2 domain (mutant) | ||
''Binary complex'' | ''Binary complex'' | ||
| Line 37: | Line 40: | ||
[[1ksw]] - hNTPK SRC kinase, SH2, SH3 domains (mutant) + benzyl ADP<br /> | [[1ksw]] - hNTPK SRC kinase, SH2, SH3 domains (mutant) + benzyl ADP<br /> | ||
[[1o41]], [[1o42]], [[1o43]], [[1o44]], [[1o45]], [[1o46]], [[1o47]], [[1o48]], [[1o49]], [[1o4a]], [[1o4b]], [[1o4c]], [[1o4d]], [[1o4e]], [[1o4f]], [[1o4g]], [[1o4h]], [[1o4j]], [[1o4i]], [[1o4k]], [[1o4l]], [[1o4m]], [[1o4n]], [[1o4o]], [[1o4p]], [[1o4q]], [[1o4r]] - hNTPK SRC SH2 domain + inhibitor<br /> | [[1o41]], [[1o42]], [[1o43]], [[1o44]], [[1o45]], [[1o46]], [[1o47]], [[1o48]], [[1o49]], [[1o4a]], [[1o4b]], [[1o4c]], [[1o4d]], [[1o4e]], [[1o4f]], [[1o4g]], [[1o4h]], [[1o4j]], [[1o4i]], [[1o4k]], [[1o4l]], [[1o4m]], [[1o4n]], [[1o4o]], [[1o4p]], [[1o4q]], [[1o4r]] - hNTPK SRC SH2 domain + inhibitor<br /> | ||
| - | [[2src]] - hNTPK SRC kinase, SH2, SH3, C terminal domains + AMP-PNP | + | [[2src]] - hNTPK SRC kinase, SH2, SH3, C terminal domains + AMP-PNP<br /> |
| + | [[1byg]] - hCSK kinase domain + staurosporine <br /> | ||
| + | [[1a07]], [[1a08]], [[1a09]], [[1a1a]], [[1a1b]], [[1a1c]], [[1a1e]] - hCSK SH2 domain + peptide ligand<br /> | ||
| + | [[1shd]] - hCSK SH2 domain + peptide inhibitor<br /> | ||
| + | [[1prl]], [[1prm]], [[1rlp]], [[1rlq]] - hCSK SH3 domain + peptide ligand<br /> | ||
| + | [[1jeg]] – CSK SH3 domain + protein-tyrosine phosphatase peptide – mouse<br /> | ||
'''Proto-oncogene tyrosine-protein kinase LCK''' | '''Proto-oncogene tyrosine-protein kinase LCK''' | ||
Revision as of 10:26, 13 February 2012
Template:STRUCTURE 1fmk
Non-receptor proto-oncogene tyrosine-protein kinase (NTPK) are enzymes which transfer a phosphate group from ATP to proteins. For details of Proto-oncogene tyrosine-protein kinase SRC see SRC.
3D structures of proto-oncogene tyrosine-protein kinase
Updated December 2011
Proto-oncogene tyrosine-protein kinase SRC
3lok, 3geq, 2qi8, 3of0 – cNTPK SRC kinase domain (mutant) – chicken
3fj5 - cNTPK SRC SH3 domain
1f2f - cNTPK SRC SH2 domain (mutant)
1yi6 – hNTPK SRC C terminal - human
1yoj - hNTPK SRC kinase domain (mutant)
1fmk - hNTPK SRC kinase, SH2, SH3, C terminal domains
1k9a – CSK – rat
3eac – hCSK SH2 domain
3eaz – hCSK SH2 domain (mutant)
Binary complex
1p13 - cNTPK SRC SH2 domain + peptide
1f1w - cNTPK SRC SH2 domain (mutant) + phosphopeptide
3g6g, 3f6x, 3el7, 3el8, 3en4, 3en5, 3en6, 3en7, 2hwo, 2hwp - cNTPK SRC kinase domain + inhibitor
3f3v, 3f3w, 3g6h, 3f3t, 3f3u, 2qlq, 2qq7, 3oez, 3svv - cNTPK SRC kinase domain (mutant) + inhibitor
3g5d - cNTPK SRC kinase domain (mutant) + cancer drug
2oiq - cNTPK SRC kinase domain + cancer drug
3dqw - cNTPK SRC kinase domain (mutant) + ATPγS
3dqx - cNTPK SRC kinase domain + ATPγS
3d7t - cNTPK SRC kinase domain + inactivator CSK (mutant)
3d7u - cNTPK SRC kinase domain + inactivator CSK
2h8h, 2bdf, 2bdj – hNTPK SRC + inhibitor – human
1yol, 1yom - hNTPK SRC kinase domain (mutant) + inhibitor
1y57 - hNTPK SRC kinase, SH2, SH3 domains + inhibitor
1ksw - hNTPK SRC kinase, SH2, SH3 domains (mutant) + benzyl ADP
1o41, 1o42, 1o43, 1o44, 1o45, 1o46, 1o47, 1o48, 1o49, 1o4a, 1o4b, 1o4c, 1o4d, 1o4e, 1o4f, 1o4g, 1o4h, 1o4j, 1o4i, 1o4k, 1o4l, 1o4m, 1o4n, 1o4o, 1o4p, 1o4q, 1o4r - hNTPK SRC SH2 domain + inhibitor
2src - hNTPK SRC kinase, SH2, SH3, C terminal domains + AMP-PNP
1byg - hCSK kinase domain + staurosporine
1a07, 1a08, 1a09, 1a1a, 1a1b, 1a1c, 1a1e - hCSK SH2 domain + peptide ligand
1shd - hCSK SH2 domain + peptide inhibitor
1prl, 1prm, 1rlp, 1rlq - hCSK SH3 domain + peptide ligand
1jeg – CSK SH3 domain + protein-tyrosine phosphatase peptide – mouse
Proto-oncogene tyrosine-protein kinase LCK
2iim - hNTPK LCK SH3 domain
1kik, 1h92 - hNTPK LCK SH3 domain - NMR
1x27 - hNTPK LCK SH2, SH3 domains
3lck - hNTPK LCK kinase domain
Binary complex
1ijr - hNTPK LCK SH2 domain + phosphotyrosine analog
1fbz - hNTPK LCK SH2 domain + inhibitor
3ad4, 3ad5, 3ad6, 3kmm, 3ac1, 3ac2, 3ac3, 3ac4, 3ac5, 3ac8, 3acj, 3ack, 3kxz, 2zyb, 3byo, 2zm1, 2zm4, 3bym, 3bys, 3byu, 3b2w, 2of2, 2of4, 2ofu, 2ofv, 2og8 – hNTPK LCK kinase domain+ inhibitor
2pl0 - hNTPK LCK kinase domain + cancer drug
Proto-oncogene tyrosine-protein kinase FYN
3h0f, 3h0h, 3h0i, 3cqt - hNTPK FYN SH3 domain (mutant)
1zbj - hNTPK FYN SH3 domain – NMR
1g83 - hNTPK FYN SH2, SH3 domains (mutant)
Binary complex
2dq7 - hNTPK FYN kinase domain + antibiotic
1m27 - hNTPK FYN SH3 domain + SH2 domain protein 1A + SLAM
Proto-oncogene tyrosine-protein kinase ABL1
3eg0, 3eg2, 3eg3, 3egu - hNTPK ABL1 SH3 domain (mutant)
2fo0 - hNTPK ABL1 SH2]], SH3 domains (mutant)
1zzp - hNTPK ABL1 F-actin binding domain – NMR
1opj, 1opk, 1opl - mNTPK ABL1 kinase domain – mouse
Binary complex
3eg1, 2o88 - hNTPK ABL1 SH3 domain (mutant) + peptide
1ju5 - hNTPK ABL1 SH3 domain + CRK SH2 domain + CRK phosphopeptide - NMR
3k2m - hNTPK ABL1 SH2 domain + monobody A4
2e2b, 2hiw - hNTPK ABL1 kinase domain + inhibitor
2f4j - hNTPK ABL1 kinase domain (mutant) + inhibitor
3cs9, 2hyy, 2hz0, 2hz4, 2hzi, 2hzn, 2gqg - hNTPK ABL1 kinase domain + cancer drug
2g1t - hNTPK ABL1 kinase domain + peptide
3ik3, 1m52, 1fpu - mNTPK ABL1 kinase domain + inhibitor
1iep - mNTPK ABL1 kinase domain + cancer drug
3dk3, 3dk6, 3dk7, 2qoh, 2v7a, 2z60 - mNTPK ABL1 kinase domain (mutant) + inhibitor
Proto-oncogene tyrosine-protein kinase FER
2kk6 - hNTPK FER SH2 domain
Proto-oncogene tyrosine-protein kinase KIT
2ec8 - hNTPK KIT extracellular domain
Binary complex
3g0e, 3g0f - hNTPK KIT kinase domain (mutant) + cancer drug
2e9w, 2o26 - hNTPK KIT extracellular domain + stem cell factor
Proto-oncogene tyrosine-protein kinase FES
3bkb - hNTPK FES kinase, SH2 domains
2dcr, 1wqu - hNTPK FES SH2 domain – NMR
Binary complex
3cd3, 3cbl - hNTPK FES kinase, SH2 domains + peptide
Proto-oncogene tyrosine-protein kinase MER
2p0c - hNTPK MER kinase domain
2dbj - hNTPK MER precursor fibronectin domain – NMR
Binary complex
3bpr - hNTPK MER kinase domain + inhibitor
3brb - hNTPK MER kinase domain + ADP
Proto-oncogene tyrosine-protein kinase YES
2hda - hNTPK YES SH3 domain
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky
