SelB
From Proteopedia
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{{STRUCTURE_1wsu| PDB=1wsu | SIZE=400| SCENE= |right|CAPTION=Elongation factor SelB C terminal complex with RNA [[1wsu]] }} | {{STRUCTURE_1wsu| PDB=1wsu | SIZE=400| SCENE= |right|CAPTION=Elongation factor SelB C terminal complex with RNA [[1wsu]] }} | ||
| - | Elongation factor SelB uses several methods to recognize the selenocysteine insertion sequence found in messenger RNA. The insertion sequence forms a hairpin loop with an unstacked guanine base in the loop. This guanine forms | + | '''Elongation factor SelB''' uses several methods to recognize the selenocysteine insertion sequence found in messenger RNA. The insertion sequence forms a hairpin loop with an unstacked guanine base in the loop. This guanine forms |
<scene name='SelB_Recognition/1wsu-recognition1/3'>specific hydrogen bonds with the protein and with two bridging water molecules (shown in cyan in the jmol).</scene> | <scene name='SelB_Recognition/1wsu-recognition1/3'>specific hydrogen bonds with the protein and with two bridging water molecules (shown in cyan in the jmol).</scene> | ||
The planar base is also sandwiched between | The planar base is also sandwiched between | ||
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{{Clear}} | {{Clear}} | ||
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| + | ==3D structures of SelB== | ||
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| + | [[1lva]] – MtSelB C terminal – ''Moorella thermoacetica''<br /> | ||
| + | [[2v9v]] - MtSelB winged-helix domains<br /> | ||
| + | [[1wb2]] – MmSelB – ''Methanococcus maripaludis'' | ||
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| + | ===SelB complex with nucleotides=== | ||
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| + | [[1wb1]] – MmSelB + GDP <br /> | ||
| + | [[1wb3]] – MmSelB + GPPNHP<br /> | ||
| + | [[1wsu]], [[2uwm]] - MtSelB C terminal + RNA<br /> | ||
| + | [[2pjp]] – EcSelB mRNA-binding domain + RNA – ''Eschrichia coli''<br /> | ||
| + | [[2ply]] - EcSelB mRNA-binding domain (mutant) + RNA | ||
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==Additional Resources== | ==Additional Resources== | ||
For additional information, see: [[Translation]] | For additional information, see: [[Translation]] | ||
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Revision as of 09:19, 14 February 2012
Elongation factor SelB uses several methods to recognize the selenocysteine insertion sequence found in messenger RNA. The insertion sequence forms a hairpin loop with an unstacked guanine base in the loop. This guanine forms The planar base is also sandwiched between in the protein, which form a tight hydrophobic pocket. This is best seen using a The overall shape of the hairpin is recognized by contacts with several In particular, notice the intimate contact formed by both the charged nitrogen and hydrophobic carbon chain of
This page complements the article on Selenocysteine Synthase in the Molecule of the Month Series. See also Teaching Scenes, Tutorials, and Educators' Pages.
3D structures of SelB
1lva – MtSelB C terminal – Moorella thermoacetica
2v9v - MtSelB winged-helix domains
1wb2 – MmSelB – Methanococcus maripaludis
SelB complex with nucleotides
1wb1 – MmSelB + GDP
1wb3 – MmSelB + GPPNHP
1wsu, 2uwm - MtSelB C terminal + RNA
2pjp – EcSelB mRNA-binding domain + RNA – Eschrichia coli
2ply - EcSelB mRNA-binding domain (mutant) + RNA
Additional Resources
For additional information, see: Translation
Proteopedia Page Contributors and Editors (what is this?)
Michal Harel, Eran Hodis, David S. Goodsell, Joel L. Sussman, David Canner, Eric Martz, Alexander Berchansky
