2onh
From Proteopedia
| Line 29: | Line 29: | ||
[[Category: monoterpene synthase]] | [[Category: monoterpene synthase]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 13 08:13:12 2008'' |
Revision as of 06:13, 13 February 2008
|
Crystal Structure of of limonene synthase with 2-fluorolinalyl diphosphate(FLPP)
Overview
The crystal structure of (4S)-limonene synthase from Mentha spic ata, a, metal ion-dependent monoterpene cyclase that catalyzes the coupled, isomerization and cyclization of geranyl diphosphate, is reported at, 2.7-A; resolution in two forms liganded to the substrate and intermediate, analogs, 2-fluorogeranyl diphosphate and 2-fluorolinalyl diphosphate, respectively. The implications of these findings are described for domain, interactions in the homodimer and for changes in diphosphate-metal ion, coordination and substrate binding conformation in the course of the, multistep reaction.
About this Structure
2ONH is a Single protein structure of sequence from Mentha spicata with , and as ligands. Known structural/functional Sites: , , , , , , , and . Full crystallographic information is available from OCA.
Reference
Structure of limonene synthase, a simple model for terpenoid cyclase catalysis., Hyatt DC, Youn B, Zhao Y, Santhamma B, Coates RM, Croteau RB, Kang C, Proc Natl Acad Sci U S A. 2007 Mar 27;104(13):5360-5. Epub 2007 Mar 19. PMID:17372193
Page seeded by OCA on Wed Feb 13 08:13:12 2008
