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4agw
From Proteopedia
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| - | + | [[Image:4agw.jpg|left|200px]] | |
| - | The | + | <!-- |
| + | The line below this paragraph, containing "STRUCTURE_4agw", creates the "Structure Box" on the page. | ||
| + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | ||
| + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | ||
| + | or leave the SCENE parameter empty for the default display. | ||
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| + | {{STRUCTURE_4agw| PDB=4agw | SCENE= }} | ||
| - | + | ===Discovery of a small molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases=== | |
| - | + | ||
| + | <!-- | ||
| + | The line below this paragraph, {{ABSTRACT_PUBMED_20299508}}, adds the Publication Abstract to the page | ||
| + | (as it appears on PubMed at http://www.pubmed.gov), where 20299508 is the PubMed ID number. | ||
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| + | {{ABSTRACT_PUBMED_20299508}} | ||
| + | |||
| + | ==About this Structure== | ||
| + | [[4agw]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4AGW OCA]. | ||
| + | |||
| + | ==Reference== | ||
| + | <ref group="xtra">PMID:020299508</ref><references group="xtra"/> | ||
| + | [[Category: Gallus gallus]] | ||
| + | [[Category: Non-specific protein-tyrosine kinase]] | ||
| + | [[Category: Choi, H G.]] | ||
| + | [[Category: Gray, N.]] | ||
| + | [[Category: Griffin, J D.]] | ||
| + | [[Category: Seeliger, M.]] | ||
| + | [[Category: Weisberg, E.]] | ||
| + | [[Category: Atp-binding]] | ||
| + | [[Category: Lipoprotein]] | ||
| + | [[Category: Myristate]] | ||
| + | [[Category: Phosphoprotein]] | ||
| + | [[Category: Sh2 domain]] | ||
| + | [[Category: Sh3 domain]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 06:41, 15 February 2012
Discovery of a small molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases
Template:ABSTRACT PUBMED 20299508
About this Structure
4agw is a 2 chain structure with sequence from Gallus gallus. Full crystallographic information is available from OCA.
Reference
- Weisberg E, Choi HG, Ray A, Barrett R, Zhang J, Sim T, Zhou W, Seeliger M, Cameron M, Azam M, Fletcher JA, Debiec-Rychter M, Mayeda M, Moreno D, Kung AL, Janne PA, Khosravi-Far R, Melo JV, Manley PW, Adamia S, Wu C, Gray N, Griffin JD. Discovery of a small-molecule type II inhibitor of wild-type and gatekeeper mutants of BCR-ABL, PDGFRalpha, Kit, and Src kinases: novel type II inhibitor of gatekeeper mutants. Blood. 2010 May 27;115(21):4206-16. Epub 2010 Mar 18. PMID:20299508 doi:10.1182/blood-2009-11-251751
