2hek
From Proteopedia
(New page: 200px<br /><applet load="2hek" size="350" color="white" frame="true" align="right" spinBox="true" caption="2hek, resolution 2.00Å" /> '''Crystal structure of...) |
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[[Image:2hek.gif|left|200px]]<br /><applet load="2hek" size="350" color="white" frame="true" align="right" spinBox="true" | [[Image:2hek.gif|left|200px]]<br /><applet load="2hek" size="350" color="white" frame="true" align="right" spinBox="true" | ||
| - | caption="2hek, resolution | + | caption="2hek, resolution 1.997Å" /> |
'''Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.'''<br /> | '''Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.'''<br /> | ||
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| + | ==Overview== | ||
| + | Using single-wavelength anomalous dispersion data obtained from a, gold-derivatized crystal, the X-ray crystal structure of the protein, 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been, determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44, kDa protein were identified by Pfam as an HD domain and a member of the, metal-dependent phosphohydrolase superfamily (accession No. PF01966)., Although three families from this large and diverse group of enzymatic, proteins are represented in the PDB, the structure of 067745_AQUAE reveals, a unique fold that is unlike the others and that is likely to represent a, new subfamily, further organizing the families and characterizing the, proteins. Data are presented that provide the first insights into the, structural organization of the proteins within this clan and a distal, alternative GDP-binding domain outside the metal-binding active site is, proposed. | ||
==About this Structure== | ==About this Structure== | ||
| - | 2HEK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand= | + | 2HEK is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Aquifex_aeolicus Aquifex aeolicus] with <scene name='pdbligand=PO4:'>PO4</scene>, <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CL:'>CL</scene>, <scene name='pdbligand=BR:'>BR</scene>, <scene name='pdbligand=GDP:'>GDP</scene> and <scene name='pdbligand=GOL:'>GOL</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Known structural/functional Sites: <scene name='pdbsite=AC1:Po4+Binding+Site+For+Residue+A+501'>AC1</scene>, <scene name='pdbsite=AC2:Po4+Binding+Site+For+Residue+B+502'>AC2</scene>, <scene name='pdbsite=AC3:Po4+Binding+Site+For+Residue+B+503'>AC3</scene>, <scene name='pdbsite=AC4:Po4+Binding+Site+For+Residue+B+504'>AC4</scene>, <scene name='pdbsite=AC5:Zn+Binding+Site+For+Residue+B+601'>AC5</scene>, <scene name='pdbsite=AC6:Zn+Binding+Site+For+Residue+A+602'>AC6</scene>, <scene name='pdbsite=AC7:Br+Binding+Site+For+Residue+B+603'>AC7</scene>, <scene name='pdbsite=AC8:Cl+Binding+Site+For+Residue+A+604'>AC8</scene>, <scene name='pdbsite=AC9:Cl+Binding+Site+For+Residue+B+605'>AC9</scene>, <scene name='pdbsite=BC1:Cl+Binding+Site+For+Residue+A+606'>BC1</scene>, <scene name='pdbsite=BC2:Cl+Binding+Site+For+Residue+B+607'>BC2</scene>, <scene name='pdbsite=BC3:Cl+Binding+Site+For+Residue+B+608'>BC3</scene>, <scene name='pdbsite=BC4:Gdp+Binding+Site+For+Residue+A+401'>BC4</scene>, <scene name='pdbsite=BC5:Gdp+Binding+Site+For+Residue+A+402'>BC5</scene>, <scene name='pdbsite=BC6:Gol+Binding+Site+For+Residue+A+403'>BC6</scene>, <scene name='pdbsite=BC7:Gol+Binding+Site+For+Residue+A+404'>BC7</scene>, <scene name='pdbsite=BC8:Gol+Binding+Site+For+Residue+B+405'>BC8</scene>, <scene name='pdbsite=BC9:Gol+Binding+Site+For+Residue+A+406'>BC9</scene>, <scene name='pdbsite=CC1:Gol+Binding+Site+For+Residue+A+407'>CC1</scene>, <scene name='pdbsite=CC2:Gol+Binding+Site+For+Residue+A+408'>CC2</scene>, <scene name='pdbsite=CC3:Gol+Binding+Site+For+Residue+B+409'>CC3</scene> and <scene name='pdbsite=CC4:Gol+Binding+Site+For+Residue+A+410'>CC4</scene>. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HEK OCA]. |
| + | |||
| + | ==Reference== | ||
| + | Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus., Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt, 5):369-74. Epub 2007 Apr 28. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=17565173 17565173] | ||
[[Category: Aquifex aeolicus]] | [[Category: Aquifex aeolicus]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
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[[Category: psi]] | [[Category: psi]] | ||
[[Category: structural genomics]] | [[Category: structural genomics]] | ||
| + | [[Category: unknown function]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 13 08:17:26 2008'' |
Revision as of 06:17, 13 February 2008
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Crystal structure of O67745, a hypothetical protein from Aquifex aeolicus at 2.0 A resolution.
Overview
Using single-wavelength anomalous dispersion data obtained from a, gold-derivatized crystal, the X-ray crystal structure of the protein, 067745_AQUAE from the prokaryotic organism Aquifex aeolicus has been, determined to a resolution of 2.0 A. Amino-acid residues 1-371 of the 44, kDa protein were identified by Pfam as an HD domain and a member of the, metal-dependent phosphohydrolase superfamily (accession No. PF01966)., Although three families from this large and diverse group of enzymatic, proteins are represented in the PDB, the structure of 067745_AQUAE reveals, a unique fold that is unlike the others and that is likely to represent a, new subfamily, further organizing the families and characterizing the, proteins. Data are presented that provide the first insights into the, structural organization of the proteins within this clan and a distal, alternative GDP-binding domain outside the metal-binding active site is, proposed.
About this Structure
2HEK is a Single protein structure of sequence from Aquifex aeolicus with , , , , and as ligands. Known structural/functional Sites: , , , , , , , , , , , , , , , , , , , , and . Full crystallographic information is available from OCA.
Reference
Structure of O67745_AQUAE, a hypothetical protein from Aquifex aeolicus., Oganesyan V, Adams PD, Jancarik J, Kim R, Kim SH, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 May 1;63(Pt, 5):369-74. Epub 2007 Apr 28. PMID:17565173
Page seeded by OCA on Wed Feb 13 08:17:26 2008
Categories: Aquifex aeolicus | Single protein | Adams, P.D. | BSGC, Berkeley.Structural.Genomics.Center. | Jancarik, J. | Kim, R. | Kim, S.H. | Oganesyan, V. | BR | CL | GDP | GOL | PO4 | ZN | Berkeley structural genomics center | Bsgc | Predominantly alpha helical protein with gdp binding site and active site being far from each other | Protein structure initiative | Psi | Structural genomics | Unknown function
