2ixh
From Proteopedia
(New page: 200px<br /> <applet load="2ixh" size="450" color="white" frame="true" align="right" spinBox="true" caption="2ixh, resolution 2.00Å" /> '''RMLC P AERUGINOSA W...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2IXH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with TRH as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IXH OCA]]. | + | 2IXH is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]] with TRH as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2IXH OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: lipopolysaccharide biosynthesis]] | [[Category: lipopolysaccharide biosynthesis]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:57:04 2007'' |
Revision as of 10:52, 30 October 2007
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RMLC P AERUGINOSA WITH DTDP-RHAMNOSE
Overview
The striking feature of carbohydrates is their constitutional, conformational and configurational diversity. Biology has harnessed this, diversity and manipulates carbohydrate residues in a variety of ways, one, of which is epimerization. RmlC catalyzes the epimerization of the C3' and, C5' positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming, dTDP-6-deoxy-L-lyxo-4-hexulose. RmlC is the third enzyme of the rhamnose, pathway, and represents a validated anti-bacterial drug target. Although, several structures of the enzyme have been reported, the mechanism and the, nature of the intermediates have remained obscure. Despite its relatively, small size (22 kDa), RmlC catalyzes four stereospecific proton transfers, and the substrate undergoes a major conformational change during the, course of ... [(full description)]
About this Structure
2IXH is a [Single protein] structure of sequence from [Pseudomonas aeruginosa] with TRH as [ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
RmlC, a C3' and C5' carbohydrate epimerase, appears to operate via an intermediate with an unusual twist boat conformation., Dong C, Major LL, Srikannathasan V, Errey JC, Giraud MF, Lam JS, Graninger M, Messner P, McNeil MR, Field RA, Whitfield C, Naismith JH, J Mol Biol. 2007 Jan 5;365(1):146-59. Epub 2006 Sep 29. PMID:17046787
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