3kgf
From Proteopedia
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==About this Structure== | ==About this Structure== | ||
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==Reference== | ==Reference== | ||
- | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:020667835</ref><ref group="xtra">PMID:016288916</ref><ref group="xtra">PMID:016142893</ref><references group="xtra"/> |
[[Category: 3-deoxy-7-phosphoheptulonate synthase]] | [[Category: 3-deoxy-7-phosphoheptulonate synthase]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] |
Revision as of 07:02, 22 February 2012
The structure of 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis complexed with phenylalanine and tryptophan
Template:ABSTRACT PUBMED 20667835
About this Structure
3kgf is a 2 chain structure with sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.
Reference
- Webby CJ, Jiao W, Hutton RD, Blackmore NJ, Baker HM, Baker EN, Jameson GB, Parker EJ. Synergistic allostery, a sophisticated regulatory network for the control of aromatic amino acid biosynthesis in Mycobacterium tuberculosis. J Biol Chem. 2010 Oct 1;285(40):30567-76. Epub 2010 Jul 27. PMID:20667835 doi:10.1074/jbc.M110.111856
- Webby CJ, Baker HM, Lott JS, Baker EN, Parker EJ. The structure of 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase from Mycobacterium tuberculosis reveals a common catalytic scaffold and ancestry for type I and type II enzymes. J Mol Biol. 2005 Dec 9;354(4):927-39. Epub 2005 Oct 21. PMID:16288916 doi:10.1016/j.jmb.2005.09.093
- Schofield LR, Anderson BF, Patchett ML, Norris GE, Jameson GB, Parker EJ. Substrate ambiguity and crystal structure of Pyrococcus furiosus 3-deoxy-D-arabino-heptulosonate-7-phosphate synthase: an ancestral 3-deoxyald-2-ulosonate-phosphate synthase? Biochemistry. 2005 Sep 13;44(36):11950-62. PMID:16142893 doi:10.1021/bi050577z
Categories: 3-deoxy-7-phosphoheptulonate synthase | Mycobacterium tuberculosis | Baker, E N. | Baker, H M. | Jameson, G B. | Jiao, W. | Parker, E J. | Webby, C J. | Aromatic biosynthesis | Augmented tim-barrel structure | Dah7p synthase | Evolutionary relationship | Mycobacterium tuberculosis structural proteomics project | Phe+trp-bound | Shikimate pathway | Structural genomic | Transferase | Xmtb