Sandbox423

From Proteopedia

Revision as of 22:52, 26 February 2012

This sandbox is in use for UMass Chemistry 423. Others please do not edit this page. Thanks!

Spring 2012 Chem423 Team Projects: Understanding the chemical basis of disease and life processes

Follow instructions posted at Student Projects for UMass Chemistry 423 Spring 2012.

Presentation dates: Teams, Topics, and Links

Note that metabolism topics are well-developed at Proteopedia (see links on course schedule), so topic suggestion # 6 will be difficult to find.

1. Jessica Royal, Anh Huynh, Stephanie Bristol, Emily Brackett - Catechol-O-methyltransferase, 2ZVJ, Parkinson's disease

2. William Yarr, Ryan Colombo, Joey Nguyen, Jacqueline Pasek-Allen - Hemoglobin 1qxd

3. Ryan Deeney, Jeffrey Boerth, Kate Liedell, Rebecca Bishop - Diabetes 2DTG (insulin receptor) also consider 3loh

4. Julia Tomaszewski, Sam Kmail, Nicole Bundy, Jesse Guillet - Caspase-6 from pdb 2WDP -- not a good choice because it's not a complex with a substrate or inhibitor: new topic needed

5. Alex Gramann, William Frantz, Felix Alfonso, Paula Preap - Bone Formation & Apoptosis & 1m4u

6. Greg Keohane, Nicole Hofstetter, Gina Lein, Louis Pires, - cisplatin, pdb code?

7. Polina Berdnikova, James Hamblin, Jill Carlson, Brett Clinton - Serpin 1JVQ -- you picked 1JVQ = same as team 8, after they picked it: new topic needed

8. Max Nowark, Kyle Reed, Kevin Dillon, Chris Carr - dementia 1JVQ

9. Di Lin, Jill Moore, Austin Virtue, Alexander Way - Caspase 3, 1RHK

10. Adam Ramey, Jeffrey Salemi, Nicholas Vecchiarello, Tom Foley - leadzyme, 1nuv

More possible topics

restriction enzyme complexes: 1rva, 1rvb, 1rvc

protein Tyr phosphatase inhibitor complexes: 1NL9, 1NNY, 1NO6

Questions & Answers

Here is a place to post questions and answers for each other about how to do things in Proteopedia. Here are some from me and previous students.

A very useful color scheme is "chain" which colors separate proteins or DNA strands in different colors (first select all protein or DNA).

Anyone know what format we should be putting our references in?

For references, follow the format used in the example on the Asp receptor and they will be put in automatically. You just find out the PMID code (listed in pubmed for example) and insert it into the following, at the place where you want the reference cited (click edit to see what is actually inserted here). ^[1] You also need to add the section:

References

1. ↑ Yeh JI, Biemann HP, Pandit J, Koshland DE, Kim SH. The three-dimensional structure of the ligand-binding domain of a wild-type bacterial chemotaxis receptor. Structural comparison to the cross-linked mutant forms and conformational changes upon ligand binding. J Biol Chem. 1993 May 5;268(13):9787-92. PMID:8486661

Hey guys this is just a useful tip: If you get an xml error after you try to save your changes it is due to the green scene coding. Our group experienced this issue and it would not let us access our sandbox. In order to fix this go back (or find the page to edit in your history) and delete the green scene code that was just entered. Then save the page and you should be back to your sandbox. This may be trivial to many, but just throwing it out there.

To highlight some interesting portion of your protein: Under the selections tab, you can "limit to residue numbers." So for example enter in 60-65, then click "replace selection" below. Then if you go to the colors tab you can pick a color for just the residues you have selected. If it is a loop or if they are hard to see you can go to the representation tab and set selection to ball and stick or spacefill.

It is also useful to click the "selection halos:" box under the picture. That shows you what you have in your selection.