3bes

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(New page: 200px<br /><applet load="3bes" size="350" color="white" frame="true" align="right" spinBox="true" caption="3bes, resolution 2.2&Aring;" /> '''Structure of a Poxvir...)
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Revision as of 06:23, 13 February 2008


3bes, resolution 2.2Å

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Structure of a Poxvirus ifngbp/ifng Complex

Overview

Ectromelia virus (ECTV) encodes an IFN-gamma-binding protein, (IFN-gammaBP(ECTV)) that disrupts IFN-gamma signaling and its ability to, induce an antiviral state within cells. IFN-gammaBP(ECTV) is an important, virulence factor that is highly conserved (>90%) in all orthopoxviruses, including variola virus, the causative agent of smallpox. The 2.2-A, crystal structure of the IFN-gammaBP(ECTV)/IFN-gamma complex reveals, IFN-gammaBP(ECTV) consists of an IFN-gammaR1 ligand-binding domain and a, 57-aa helix-turn-helix (HTH) motif that is structurally related to the, transcription factor TFIIA. The HTH motif forms a tetramerization domain, that results in an IFN-gammaBP(ECTV)/IFN-gamma complex containing four, IFN-gammaBP(ECTV) chains and two IFN-gamma dimers. The structure, combined, with biochemical and cell-based assays, demonstrates that, IFN-gammaBP(ECTV) tetramers are required for efficient IFN-gamma, antagonism.

About this Structure

3BES is a Protein complex structure of sequences from Ectromelia virus and Homo sapiens with and as ligands. Known structural/functional Sites: , , , , , and . Full crystallographic information is available from OCA.

Reference

Structure and mechanism of IFN-{gamma} antagonism by an orthopoxvirus IFN-{gamma}-binding protein., Nuara AA, Walter LJ, Logsdon NJ, Yoon SI, Jones BC, Schriewer JM, Buller RM, Walter MR, Proc Natl Acad Sci U S A. 2008 Feb 5;. PMID:18252829

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