1b2v
From Proteopedia
(New page: 200px<br /> <applet load="1b2v" size="450" color="white" frame="true" align="right" spinBox="true" caption="1b2v, resolution 1.9Å" /> '''HEME-BINDING PROTEIN...) |
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| - | [[Image:1b2v. | + | [[Image:1b2v.jpg|left|200px]]<br /><applet load="1b2v" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1b2v" size=" | + | |
caption="1b2v, resolution 1.9Å" /> | caption="1b2v, resolution 1.9Å" /> | ||
'''HEME-BINDING PROTEIN A'''<br /> | '''HEME-BINDING PROTEIN A'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1B2V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens] with CA and HEM as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http:// | + | 1B2V is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Serratia_marcescens Serratia marcescens] with <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=HEM:'>HEM</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1B2V OCA]. |
==Reference== | ==Reference== | ||
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[[Category: iron metabolism]] | [[Category: iron metabolism]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:30:36 2008'' |
Revision as of 13:30, 15 February 2008
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HEME-BINDING PROTEIN A
Overview
Free iron availability is strongly limited in vertebrate hosts, making the, iron acquisition by siderophores inappropriate. Pathogenic bacteria have, developed various ways to use the host's iron from iron-containing, proteins. Serratia marcescens can use the iron from hemoglobin through the, secretion of a hemophore called HasA, which takes up the heme from, hemoglobin and shuttles it to the receptor HasR, which in turn, releases, heme into the bacterium. We report here the first crystal structure of, such a hemophore, bound to a heme group at two different pH values and at, a resolution of 1.9 A. The structure reveals a new original fold and, suggests a hypothetical mechanism for both heme uptake and release.
About this Structure
1B2V is a Single protein structure of sequence from Serratia marcescens with and as ligands. Full crystallographic information is available from OCA.
Reference
The crystal structure of HasA, a hemophore secreted by Serratia marcescens., Arnoux P, Haser R, Izadi N, Lecroisey A, Delepierre M, Wandersman C, Czjzek M, Nat Struct Biol. 1999 Jun;6(6):516-20. PMID:10360351
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