Chromodomain-helicase-DNA-binding protein
From Proteopedia
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'''Chromodomain-helicase-DNA-binding protein''' (CHD) remodel chromatin and histone deacylation thus affecting transcription. Chromatin regulation involves the tightness of packing of DNA. When DNA is tightly packed, gene expression is slower. | '''Chromodomain-helicase-DNA-binding protein''' (CHD) remodel chromatin and histone deacylation thus affecting transcription. Chromatin regulation involves the tightness of packing of DNA. When DNA is tightly packed, gene expression is slower. | ||
| - | + | ==3D structures of CHD== | |
[[2b2t]] – hCHD1 (mutant) + histone H3 tail – human<br /> | [[2b2t]] – hCHD1 (mutant) + histone H3 tail – human<br /> | ||
Revision as of 11:16, 4 March 2012
Chromodomain-helicase-DNA-binding protein (CHD) remodel chromatin and histone deacylation thus affecting transcription. Chromatin regulation involves the tightness of packing of DNA. When DNA is tightly packed, gene expression is slower.
3D structures of CHD
2b2t – hCHD1 (mutant) + histone H3 tail – human
2b2u, 2b2v, 2b2w - hCHD1 + histone H3 tail
2b2y - hCHD1
2l5u – hCHD4 PHD finger 1 – NMR
2l75 - hCHD4 PHD finger 2 + histone H3 peptide – NMR
2ee1 – hCHD4 chromodomain – NMR
2epb – hCHD6 chromodomain 2 – NMR
2ckc, 2v0e, 2v0f – hCHD7 BRK domain - NMR
2dl6, 2cka – hCHD8 BRK domain - NMR
