Penicillin-binding protein
From Proteopedia
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| + | {{STRUCTURE_2ex6| PDB=2ex6 | SIZE=400| SCENE= |right|CAPTION=E. coli PBP 4 complex with antibiotic [[2ex6]]}} | ||
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| + | '''Penicillin-binding protein''' (PBP) is a bacterial protein which binds antibiotics. There are several PBPs in each organism. PBPs are involved in the synthesis of bacterial cell wall. Their inhibition by antibiotics leads to irregularities in the cell wall and eventual bacterial death. The PBP are classified to high-molecular weight and low-molecular weight groups. | ||
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| + | ==3D structures of penicillin-binding protein== | ||
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| + | [[1qme]], [[1rp5]], [[2z2l]] – SpPBP 2X – ''Streptococcus pneumoniae''<br /> | ||
| + | [[1k25]], [[1pyy]] – SpPBP 2X (mutant) <br /> | ||
| + | [[2fff]] - SpPBP 1B<br /> | ||
| + | [[2bg1]], [[2xd5]] - SpPBP 1B (mutant) <br /> | ||
| + | [[2c6w]] - SpPBP 1A <br /> | ||
| + | [[2wad]], [[2wae]], [[2waf]] – SpPBP 2B<br /> | ||
| + | [[1hd8]], [[1nj4]], [[1sdn]] – EcPBP 5 (mutant) – ''Escherichia coli''<br /> | ||
| + | [[2ex2]] – EcPBP 4<br /> | ||
| + | [[1nzo]], [[1nzu]] – EcPBP 5<br /> | ||
| + | [[3it9]] – EcPBP 6<br /> | ||
| + | [[1mwr]], [[1vqq]] - SaPBP 2A (mutant) – ''Staphylococcus aureus''<br /> | ||
| + | [[2olu]], [[3dwk]] – SaPBP 2<br /> | ||
| + | [[1w5d]] – BsPBP 4A – ''Bacillus subtilis''<br /> | ||
| + | [[3mfd]] – BsPBP 5*<br /> | ||
| + | [[2oqo]] – AaPBP 1A – ''Aquifex aeolicus''<br /> | ||
| + | [[3equ]] – NgPBP 2 – ''Neisseria gonorrhoeae''<br /> | ||
| + | [[3eqv]] – NgPBP 2 (mutant) <br /> | ||
| + | [[3a3d]] – HiPBP 4 – ''Haemophilus influenza''<br /> | ||
| + | [[1lo7]] – PBP A – ''Mycobacterium tuberculosis''<br /> | ||
| + | [[3oc2]], [[3pbn]] – PaPBP 3 – ''Pseudomonas aeruginosa''<br /> | ||
| + | [[3tg9]] – PBP – ''Bacillus halodurans''<br /> | ||
| + | [[3udf]] – AbPBP – ''Acinetobacter baumannii'' | ||
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| + | '''PBP complex with antibiotics''' | ||
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| + | [[1qmf]], [[2z2m]], [[2zc3]], [[2zc4]], [[2zc5]], [[2zc6]] – SpPBP 2X + antibiotic<br /> | ||
| + | [[1mws]] - SaPBP 2A (mutant) + nitrocefin<br /> | ||
| + | [[1mwu]], [[1mwt]] - SaPBP 2A (mutant) + antibiotic<br /> | ||
| + | [[2uwx]] - SaPBP 1B (mutant) + nitrocefin<br /> | ||
| + | [[2olv]] - SaPBP 2 + antibiotic<br /> | ||
| + | [[3hum]], [[3hun]] - SaPBP 4 (mutant) + antibiotic<br /> | ||
| + | [[2c5w]] - SpPBP 1A + antibiotic<br /> | ||
| + | [[2jch]], [[2je5]], [[2xd1]] - SpPBP 1B (mutant) + antibiotic<br /> | ||
| + | [[2ex6]], [[2ex8]], [[2ex9]], [[2exa]], [[2exb]] - EcPBP 4 + antibiotic<br /> | ||
| + | [[3beb]], [[3bec]], [[3mzd]], [[3mze]], [[3mzf]] - EcPBP 5 + antibiotic<br /> | ||
| + | [[3ita]] - EcPBP 6 + antibiotic<br /> | ||
| + | [[3fwl]], [[3fwm]] – EcPBP 1B + antibiotic<br /> | ||
| + | [[2wke]] - AcPBP + antibiotic – ''Actinomadura''<br /> | ||
| + | [[3a3e]], [[3a3f]], [[3a3i]] – HiPBP 4 + antibiotic<br /> | ||
| + | [[3ocl]], [[3ocn]], [[3pbo]], [[3pbq]], [[3pbr]], [[3pbs]], [[3pbt]] – PaPBP 3 + antibiotic<br /> | ||
| + | [[3nb6]], [[3nb7]] - AaPBP 1A + antibiotic<br /> | ||
| + | [[3udi]], [[3udx]], [[3ue0]], [[3ue1]] - AbPBP + antibiotic<br /> | ||
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| + | '''PBP complex with boronic acid derivatives''' | ||
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| + | [[1z6f]] – EcPBP 5 + boronic acid<br /> | ||
| + | [[2xdm]], [[2xk1]], [[2xln]], [[2y4a]], [[2y55]], [[2y59]], [[3zvt]], [[3zvw]] – AcPBP + boronic acid derivative<br /> | ||
| + | [[2y2g]], [[2y2h]], [[2y2i]], [[2y2j]], [[2y2k]], [[2y2l]], [[2y2m]], [[2y2n]], [[2y2o]], [[2y2p]], [[2y2q]] - SpPBP 1B + boronic acid derivative | ||
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| + | '''PBP complex with peptidoglycan''' | ||
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| + | [[3itb]] - EcPBP 6 + peptidoglycan peptide<br /> | ||
| + | [[2j9p]] - BsPBP 4A + peptidoglycan peptide | ||
Revision as of 11:41, 4 March 2012
Penicillin-binding protein (PBP) is a bacterial protein which binds antibiotics. There are several PBPs in each organism. PBPs are involved in the synthesis of bacterial cell wall. Their inhibition by antibiotics leads to irregularities in the cell wall and eventual bacterial death. The PBP are classified to high-molecular weight and low-molecular weight groups.
3D structures of penicillin-binding protein
1qme, 1rp5, 2z2l – SpPBP 2X – Streptococcus pneumoniae
1k25, 1pyy – SpPBP 2X (mutant)
2fff - SpPBP 1B
2bg1, 2xd5 - SpPBP 1B (mutant)
2c6w - SpPBP 1A
2wad, 2wae, 2waf – SpPBP 2B
1hd8, 1nj4, 1sdn – EcPBP 5 (mutant) – Escherichia coli
2ex2 – EcPBP 4
1nzo, 1nzu – EcPBP 5
3it9 – EcPBP 6
1mwr, 1vqq - SaPBP 2A (mutant) – Staphylococcus aureus
2olu, 3dwk – SaPBP 2
1w5d – BsPBP 4A – Bacillus subtilis
3mfd – BsPBP 5*
2oqo – AaPBP 1A – Aquifex aeolicus
3equ – NgPBP 2 – Neisseria gonorrhoeae
3eqv – NgPBP 2 (mutant)
3a3d – HiPBP 4 – Haemophilus influenza
1lo7 – PBP A – Mycobacterium tuberculosis
3oc2, 3pbn – PaPBP 3 – Pseudomonas aeruginosa
3tg9 – PBP – Bacillus halodurans
3udf – AbPBP – Acinetobacter baumannii
PBP complex with antibiotics
1qmf, 2z2m, 2zc3, 2zc4, 2zc5, 2zc6 – SpPBP 2X + antibiotic
1mws - SaPBP 2A (mutant) + nitrocefin
1mwu, 1mwt - SaPBP 2A (mutant) + antibiotic
2uwx - SaPBP 1B (mutant) + nitrocefin
2olv - SaPBP 2 + antibiotic
3hum, 3hun - SaPBP 4 (mutant) + antibiotic
2c5w - SpPBP 1A + antibiotic
2jch, 2je5, 2xd1 - SpPBP 1B (mutant) + antibiotic
2ex6, 2ex8, 2ex9, 2exa, 2exb - EcPBP 4 + antibiotic
3beb, 3bec, 3mzd, 3mze, 3mzf - EcPBP 5 + antibiotic
3ita - EcPBP 6 + antibiotic
3fwl, 3fwm – EcPBP 1B + antibiotic
2wke - AcPBP + antibiotic – Actinomadura
3a3e, 3a3f, 3a3i – HiPBP 4 + antibiotic
3ocl, 3ocn, 3pbo, 3pbq, 3pbr, 3pbs, 3pbt – PaPBP 3 + antibiotic
3nb6, 3nb7 - AaPBP 1A + antibiotic
3udi, 3udx, 3ue0, 3ue1 - AbPBP + antibiotic
PBP complex with boronic acid derivatives
1z6f – EcPBP 5 + boronic acid
2xdm, 2xk1, 2xln, 2y4a, 2y55, 2y59, 3zvt, 3zvw – AcPBP + boronic acid derivative
2y2g, 2y2h, 2y2i, 2y2j, 2y2k, 2y2l, 2y2m, 2y2n, 2y2o, 2y2p, 2y2q - SpPBP 1B + boronic acid derivative
PBP complex with peptidoglycan
3itb - EcPBP 6 + peptidoglycan peptide
2j9p - BsPBP 4A + peptidoglycan peptide
