Sandbox Reserved 430
From Proteopedia
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===Binding Interactions=== | ===Binding Interactions=== | ||
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| + | Cisplatin Binds to DNA by a a 1,2 intrastrand DNA cross link. | ||
| + | The distortion to the structure of DNA caused by the cisplatin cross links allows the recognition of HMG domain protiens to bind to the DNA. | ||
| + | DNA containing platinum lesions show a shift from right handed B to left hand Z DNA | ||
| + | A <Structure load='1a84' size='500' frame='true' align='right' caption='kink' scene='Insert optional scene name here' /> site in the major groove at the platinum coordination (20,21)was observed to be caused by the cisplatin 1,2-intrastrand cross link to the double helix. | ||
===Credits=== | ===Credits=== | ||
Revision as of 04:45, 5 March 2012
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| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Contents |
Cisplatin-DNA complex- 1a84
Introduction
In this figure is to a 12 base pair double stranded DNA, creating a 49° bend with an overall helix bend of 78°. This bend in the DNA is crucial to cisplatin’s role as an anticancer drug. Cisplatin, cis-PtCl2(NH3)2, is a chemotherapy drug, administered intravenously, used in the treatment of various types of cancer. This platinum-based drug acts in vivo by binding to two consecutive adjacent guanine bases in DNA. The binding of cisplatin bends the DNA, allowing for HMG-protein to bind. Once the HMG-protein is bound, de-stacking of the nucleotide base pairs occurs, which in turn kinks the DNA. With the HMG-protein bound to the DNA, the cell cannot properly repair the DNA, leading to apoptosis.
Overall Structure
Binding Interactions
=Additional Features
Cisplatin Binds to DNA by a a 1,2 intrastrand DNA cross link. The distortion to the structure of DNA caused by the cisplatin cross links allows the recognition of HMG domain protiens to bind to the DNA. DNA containing platinum lesions show a shift from right handed B to left hand Z DNA
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Credits
Introduction - Gina Lein
Overall Structure - name of team member
Drug Binding Site - name of team member
Additional Features - name of team member
