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Sandbox Reserved 425
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===Binding Interactions=== | ===Binding Interactions=== | ||
| + | Met 40, Leu 198, Tyr 200, Trp 38, and Pro 174 pocket for 4-phenyl-7, 8-dihydroxycoumarine (4PCM) | ||
| + | <scene name='Sandbox_Reserved_425/Binding1/1'>Binding1</scene> | ||
===Additional Features=== | ===Additional Features=== | ||
Revision as of 08:38, 5 March 2012
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| This Sandbox is Reserved from January 19, 2016, through August 31, 2016 for use for Proteopedia Team Projects by the class Chemistry 423 Biochemistry for Chemists taught by Lynmarie K Thompson at University of Massachusetts Amherst, USA. This reservation includes Sandbox Reserved 425 through Sandbox Reserved 439. |
Contents |
YourMacromolecule
Introduction
- COMT responsible for degradation of catchol neurotransmitters including DA
- PD symptoms result from low levels of DA
- inhibiting COMT has potential to treat PD in conjunction with L-DOPA (a DA precursor currently used to treat PD) by increasing the bioavailability and stability of L-DOPA
- 4PCM is a COMT inhibitor being studied to better understand inhibitor interactions with COMT in order to develop better inhibitors
- carbonyl oxygen of 4PCM interacts with
Overall Structure
Biological Unit with DNA - green scene
Polar/nonpolar regions green scene
Secondary Structure green scene
-alpha helixes-phi and psi angles in one helix-how many-location
-beta sheets-kinds-how many-locations
Ligand structure KOM-AC3, MG-AC1, SAM-AC2 ball and stick green scene
Binding Interactions
Met 40, Leu 198, Tyr 200, Trp 38, and Pro 174 pocket for 4-phenyl-7, 8-dihydroxycoumarine (4PCM)
Additional Features
Credits
Introduction - Jessica Royal
Overall Structure - Stephanie Bristol
Drug Binding Site - Emily Brackett
Additional Features - Anh Huynh
