1biw
From Proteopedia
(New page: 200px<br /> <applet load="1biw" size="450" color="white" frame="true" align="right" spinBox="true" caption="1biw, resolution 2.5Å" /> '''DESIGN AND SYNTHESIS...) |
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caption="1biw, resolution 2.5Å" /> | caption="1biw, resolution 2.5Å" /> | ||
'''DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS'''<br /> | '''DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BIW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with ZN, CA and S80 as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Full crystallographic information is available from [http:// | + | 1BIW is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=ZN:'>ZN</scene>, <scene name='pdbligand=CA:'>CA</scene> and <scene name='pdbligand=S80:'>S80</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/Stromelysin_1 Stromelysin 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.17 3.4.24.17] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BIW OCA]. |
==Reference== | ==Reference== | ||
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[[Category: structure-based drug design]] | [[Category: structure-based drug design]] | ||
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Revision as of 13:32, 15 February 2008
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DESIGN AND SYNTHESIS OF CONFORMATIONALLY-CONSTRAINED MMP INHIBITORS
Contents |
Overview
A novel series of conformationally constrained matrix metalloprotease, inhibitors was identified. The potencies observed for these inhibitors, were highly dependent upon the substitution pattern on the caprolactam, ring as well as the succinate moiety.
Disease
Known diseases associated with this structure: Coronary heart disease, susceptibility to OMIM:[185250]
About this Structure
1BIW is a Single protein structure of sequence from Homo sapiens with , and as ligands. Active as Stromelysin 1, with EC number 3.4.24.17 Full crystallographic information is available from OCA.
Reference
Design and synthesis of conformationally-constrained MMP inhibitors., Natchus MG, Cheng M, Wahl CT, Pikul S, Almstead NG, Bradley RS, Taiwo YO, Mieling GE, Dunaway CM, Snider CE, McIver JM, Barnett BL, McPhail SJ, Anastasio MB, De B, Bioorg Med Chem Lett. 1998 Aug 18;8(16):2077-80. PMID:9873489
Page seeded by OCA on Fri Feb 15 15:32:20 2008
Categories: Homo sapiens | Single protein | Stromelysin 1 | Almstead, N.G. | Anastasio, M.B. | Barnett, B.L. | Bradley, R.S. | Cheng, M. | De, B. | Dunaway, C.M. | McIver, J.M. | McPhail, S.J. | Mieling, G.E. | Natchus, M.G. | Pikul, S. | Snider, C.E. | Taiwo, Y.O. | Wahl, C.T. | CA | S80 | ZN | Matrix metalloprotease | Osteoarthritis | Protein crystal structure | Stromelysin | Structure-based drug design
