Ketohexokinase
From Proteopedia
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Michal Harel (Talk | contribs)
(New page: {{STRUCTURE_3nbv| PDB=3nbv | SIZE=400| SCENE= |right|CAPTION=Ketohexokinase complex with fructose and AMPPNP 3nbv }} <!-- Please use the "3D" button above this box to insert a Jmol...)
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Revision as of 11:07, 5 March 2012
Ketohexokinase (KHK) also known as hepatic fructokinase catalyzes the phosphorylation of fructose to fructose-1-phosphate using ATP as phosphate source in the liver. The HKH gene is spliced to HKH-A and the more active HKH-C. HKH deficiency causes the essential fructosuria disorder. KHK acts in the first step of fructose metabolism.
3D structuresm of ketohexokinase
2hlz, 2hqq, 3b3l – hKHK – human 2hw1, 3nbv – hKHK + AMPPNP + fructose 3nbw – hKHK + pyrazole derivative 2nc2, 3nc9, 3nca, 3ro4, 3q92, 3qa2, 3qai – hKHK + inhibitor
