1bj5
From Proteopedia
(New page: 200px<br /> <applet load="1bj5" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bj5, resolution 2.5Å" /> '''HUMAN SERUM ALBUMIN ...) |
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| - | [[Image:1bj5. | + | [[Image:1bj5.jpg|left|200px]]<br /><applet load="1bj5" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1bj5" size=" | + | |
caption="1bj5, resolution 2.5Å" /> | caption="1bj5, resolution 2.5Å" /> | ||
'''HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID'''<br /> | '''HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1BJ5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MYR as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1BJ5 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=MYR:'>MYR</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BJ5 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: plasma protein]] | [[Category: plasma protein]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:32:23 2008'' |
Revision as of 13:32, 15 February 2008
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HUMAN SERUM ALBUMIN COMPLEXED WITH MYRISTIC ACID
Contents |
Overview
Human serum albumin (HSA) is the most abundant protein in the circulatory, system. Its principal function is to transport fatty acids, but it is also, capable of binding a great variety of metabolites and drugs. Despite, intensive efforts, the detailed structural basis of fatty acid binding to, HSA has remained elusive. We have now determined the crystal structure of, HSA complexed with five molecules of myristate at 2.5 A resolution. The, fatty acid molecules bind in long, hydrophobic pockets capped by polar, side chains, many of which are basic. These pockets are distributed, asymmetrically throughout the HSA molecule, despite its symmetrical, repeating domain structure.
Disease
Known diseases associated with this structure: Analbuminemia OMIM:[103600], Dysalbuminemic hyperthyroxinemia OMIM:[103600], Dysalbuminemic hyperzincemia OMIM:[103600]
About this Structure
1BJ5 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of human serum albumin complexed with fatty acid reveals an asymmetric distribution of binding sites., Curry S, Mandelkow H, Brick P, Franks N, Nat Struct Biol. 1998 Sep;5(9):827-35. PMID:9731778
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