Journal:JMB:2
From Proteopedia
(Difference between revisions)
| Line 4: | Line 4: | ||
<hr/> | <hr/> | ||
<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
| - | Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; | + | Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; <scene name='Journal:JMB:2/2a/4'> (A)</scene> 2HQ and the |
| - | structured active-site loop in the rePON1-2HQ complex structure. | + | structured active-site loop in the rePON1-2HQ complex structure. <scene name='Journal:JMB:2/2b/1'>(B)</scene> Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ |
| - | + | in the rePON1-2HQ complex. <scene name='Journal:JMB:2/2c/1'>(C)</scene> The first segment of the active-site loop, and residues Y71 | |
| - | in the rePON1-2HQ complex. | + | and I74 in particular, comprises part of PON1's active-site wall. <scene name='Journal:JMB:2/2d/2'>(D)</scene> Interactions of 2HQ with |
| - | and I74 in particular, comprises part of PON1's active-site wall. | + | |
active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | ||
| - | |||
| - | Figure 3. Changes in the rePON1 binding site upon binding of 2HQ. Superimposition of the | ||
| - | rePON1-2HQ complex (cyan;; the closed conformation) with the apo rePON1 structures at pH | ||
| - | 4.5 (orange) and pH 6.5 (blue) (the open conformations). The pH 4.5 conformation prevents | ||
| - | closure of the active-site loop due to clashes of F347 and H348 with the loop residues (e.g. | ||
| - | F77 and I74). Also illustrated is the movement of Y71 (dashed arrow) upon binding of 2HQ, | ||
| - | and its interaction with D183 in the 2HQ complex structure. | ||
| - | |||
| - | |||
<references/> | <references/> | ||
__NOEDITSECTION__ | __NOEDITSECTION__ | ||
Revision as of 17:11, 6 March 2012
|
Title Of The Paper
Authors[1]
Molecular Tour
Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; 2HQ and the
structured active-site loop in the rePON1-2HQ complex structure. Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ
in the rePON1-2HQ complex. The first segment of the active-site loop, and residues Y71
and I74 in particular, comprises part of PON1's active-site wall. Interactions of 2HQ with
active-site residues (interactions with the catalytic Ca2+ are highlighted in red).
- ↑ none yet
Proteopedia Page Contributors and Editors (what is this?)
This page complements a publication in scientific journals and is one of the Proteopedia's Interactive 3D Complement pages. For aditional details please see I3DC.
