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Journal:JMB:2
From Proteopedia
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| - | <applet load="Workbench_test2.pdb" size="500" color="" frame="true" spin="on" Scene ='Journal:JMB:2/Opening/1' align="right" caption=" | + | <applet load="Workbench_test2.pdb" size="500" color="" frame="true" spin="on" Scene ='Journal:JMB:2/Opening/1' align="right" caption=" rePON1 with 2HQ ''"/> |
=== Catalytic versatility and backups in enzyme active sites: The case of serum paraoxanase 1 === | === Catalytic versatility and backups in enzyme active sites: The case of serum paraoxanase 1 === | ||
<big>Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Dunach, Israel Silman, Joel Sussman and Dan Tawfik, PhD</big><ref >none yet</ref> | <big>Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Dunach, Israel Silman, Joel Sussman and Dan Tawfik, PhD</big><ref >none yet</ref> | ||
<hr/> | <hr/> | ||
<b>Molecular Tour</b><br> | <b>Molecular Tour</b><br> | ||
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Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; <scene name='Journal:JMB:2/2a/4'> (A)</scene> 2HQ and the | Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; <scene name='Journal:JMB:2/2a/4'> (A)</scene> 2HQ and the | ||
structured active-site loop in the rePON1-2HQ complex structure. <scene name='Journal:JMB:2/2b/1'>(B)</scene> Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ | structured active-site loop in the rePON1-2HQ complex structure. <scene name='Journal:JMB:2/2b/1'>(B)</scene> Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ | ||
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and I74 in particular, comprises part of PON1's active-site wall. <scene name='Journal:JMB:2/2d/2'>(D)</scene> Interactions of 2HQ with | and I74 in particular, comprises part of PON1's active-site wall. <scene name='Journal:JMB:2/2d/2'>(D)</scene> Interactions of 2HQ with | ||
active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | active-site residues (interactions with the catalytic Ca2+ are highlighted in red). | ||
| - | < | + | |
| - | < | + | <table width='1000' align='center' cellpadding='2'><td rowspan='2'> </td><td bgcolor='#eeeeee'> |
| - | < | + | <center>'''rePON1 with 2HQ''' </center><applet load='Workbench_test2.pdb' size='325' frame='true' align='left' scene="" target='0' /></td><td bgcolor='#eeeeee'> |
| - | + | <center>'''rePON1 at pH of 6.5''' </center><applet load='Workbench_test3.pdb' size='325' frame='true' align='center' scene="" target='0' /></td><td bgcolor='#eeeeee'> | |
| + | <center>'''rePON1 at pH of 4.5''' </center><applet load='1V04' size='325' frame='true' align='right' scene="" target='0' /></td><td bgcolor='#eeeeee'> | ||
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<references/> | <references/> | ||
__NOEDITSECTION__ | __NOEDITSECTION__ | ||
Revision as of 18:46, 6 March 2012
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Catalytic versatility and backups in enzyme active sites: The case of serum paraoxanase 1
Moshe Ben-David, Mikael Elias, Jean-Jacques Filippi, Elisabet Dunach, Israel Silman, Joel Sussman and Dan Tawfik, PhD[1]
Molecular Tour
Figure 2. Structural details of the 2HQ/rePON1 complex at pH 6.5; 2HQ and the structured active-site loop in the rePON1-2HQ complex structure. Overlay of the phosphate ion in the apo rePON1 at pH 6.5 and of 2HQ in the rePON1-2HQ complex. The first segment of the active-site loop, and residues Y71 and I74 in particular, comprises part of PON1's active-site wall. Interactions of 2HQ with active-site residues (interactions with the catalytic Ca2+ are highlighted in red).
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