3sgy

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'''Unreleased structure'''
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[[Image:3sgy.jpg|left|200px]]
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The entry 3sgy is ON HOLD until Paper Publication
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{{STRUCTURE_3sgy| PDB=3sgy | SCENE= }}
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Authors: Frey, K.M., Anderson, A.C.
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===Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)===
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Description: Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)
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{{ABSTRACT_PUBMED_22347365}}
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==About this Structure==
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[[3sgy]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SGY OCA].
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==Reference==
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<ref group="xtra">PMID:022347365</ref><references group="xtra"/>
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[[Category: Dihydrofolate reductase]]
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[[Category: Staphylococcus aureus]]
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[[Category: Anderson, A C.]]
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[[Category: Frey, K M.]]
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[[Category: Nadp]]
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[[Category: Nadph]]
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[[Category: One-carbon metabolism]]
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[[Category: Oxidoreductase]]
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[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

Revision as of 05:48, 8 March 2012

Image:3sgy.jpg

Template:STRUCTURE 3sgy

Staphylococcus aureus Dihydrofolate Reductase complexed with NADPH and 6-ETHYL-5-[(3S)-3-[3-METHOXY-5-(PYRIDIN-4-YL)PHENYL]BUT-1-YN-1-YL]PYRIMIDINE-2,4-DIAMINE (UCP1006)

Template:ABSTRACT PUBMED 22347365

About this Structure

3sgy is a 2 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

  • Viswanathan K, Frey KM, Scocchera EW, Martin BD, Swain Iii PW, Alverson JB, Priestley ND, Anderson AC, Wright DL. Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes. PLoS One. 2012;7(2):e29434. Epub 2012 Feb 7. PMID:22347365 doi:10.1371/journal.pone.0029434

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OCA

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