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1cos
From Proteopedia
(New page: 200px<br /> <applet load="1cos" size="450" color="white" frame="true" align="right" spinBox="true" caption="1cos, resolution 2.1Å" /> '''CRYSTAL STRUCTURE OF...) |
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caption="1cos, resolution 2.1Å" /> | caption="1cos, resolution 2.1Å" /> | ||
'''CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE'''<br /> | '''CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1COS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with ACE and NH2 as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1COS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http:// | + | 1COS is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/ ] with <scene name='pdbligand=ACE:'>ACE</scene> and <scene name='pdbligand=NH2:'>NH2</scene> as [http://en.wikipedia.org/wiki/ligands ligands]. The following page contains interesting information on the relation of 1COS with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1COS OCA]. |
==Reference== | ==Reference== | ||
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[[Category: alpha-helical bundle]] | [[Category: alpha-helical bundle]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:36:28 2008'' |
Revision as of 13:36, 15 February 2008
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CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE
Overview
The x-ray crystal structure of a peptide designed to form a, double-stranded parallel coiled coil shows that it is actually a, triple-stranded coiled coil formed by three alpha-helices. Unlike the, designed parallel coiled coil, the helices run up-up-down. The structure, is stabilized by a distinctive hydrophobic interface consisting of eight, layers. As in the design, each alpha-helix in the coiled coil contributes, one leucine side chain to each layer. The structure suggests that, hydrophobic interactions are a dominant factor in the stabilization of, coiled coils. The stoichiometry and geometry of coiled coils are primarily, determined by side chain packing in the solvent-inaccessible interior, but, electrostatic interactions also contribute.
About this Structure
1COS is a Protein complex structure of sequences from [1] with and as ligands. The following page contains interesting information on the relation of 1COS with [Designer Proteins]. Full crystallographic information is available from OCA.
Reference
Crystal structure of a synthetic triple-stranded alpha-helical bundle., Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D, Science. 1993 Feb 26;259(5099):1288-93. PMID:8446897
Page seeded by OCA on Fri Feb 15 15:36:28 2008
