1cr8

From Proteopedia

Revision as of 13:36, 15 February 2008

LOW DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN COMPLEMENT REPEAT 8

Overview

The low density lipoprotein receptor-related protein is a member of the, low density lipoprotein receptor family and contains clusters of, cysteine-rich complement-like repeats of about 42 residues that are, present in all members of this family of receptors. These clusters are, thought to be the principal binding sites for protein ligands. We have, expressed one complement-like repeat, CR8, from the cluster in lipoprotein, receptor-related protein that binds certain proteinase, inhibitor-proteinase complexes and used three-dimensional NMR on the, 13C/15N-labeled protein to determine the structure in solution of the, calcium-bound form. The structure is very similar in overall fold to, repeat 5 from the low density lipoprotein receptor (LB5), with backbone, root mean square deviation of 1.5 A. The calcium-binding site also appears, to be homologous, with four carboxyl and two backbone carbonyl ligands., However, differences in primary structure are such that equivalent, surfaces that might represent the binding interfaces are very different, from one another, indicating that different domains will have very, different ligand specificities.

Disease

Known diseases associated with this structure: Leigh syndrome, French-Canadian type OMIM:[607544], Urolithiasis, 2,8-dihydroxyadenine OMIM:[102600]

About this Structure

1CR8 is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.

Reference

NMR solution structure of complement-like repeat CR8 from the low density lipoprotein receptor-related protein., Huang W, Dolmer K, Gettins PG, J Biol Chem. 1999 May 14;274(20):14130-6. PMID:10318830

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