Retinoblastoma-binding protein
From Proteopedia
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| + | {{STRUCTURE_3cfs| PDB=3cfs | SIZE=400| SCENE=|right|CAPTION=Human retinoblastoma-binding protein 7 complex with histone H4 [[3cfs]] }} | ||
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Revision as of 10:25, 13 March 2012
Retinoblastoma-binding protein (RBBP) are nuclear proteins implicated in the regulation of transcription and differentiation by the retinoblastoma tumor suppressor protein. RBBP1 regulates transcriptional activity. RBBP2 demethylates histone H3K4. RBBP5 is involved in methylation and dimethylation of histone H3. RBBP9 blocks the binding of retinoblastoma protein to one of its signaling partners.
3D structures of retinoblastoma-binding protein
RBBP1
2yrv, 2lcc – hRBBP1 AT-rich interactive domain – human – NMR
RBBP2
2jxj – hRBBP2 ARID domain + histone H3K4 – NMR
2kgg – hRBBP2 C terminal PHD zinc finger – NMR
2kgi - hRBBP2 C terminal PHD zinc finger + histone H3K4 – NMR
3gl6 - hRBBP2 C terminal PHD zinc finger + histone H3 N terminal
RBBP4
3gfc – hRBBP4
2xu7 – hRBBP4 + zinc finger protein ZFPM1 RBBP4-binding domain
RBBP6
2c7h – hRBBP6 DWNN domain – NMR
2ysa - hRBBP6 zinc finger CCHC domain – NMR
2yur, 3ztg - hRBBP6 ring finger domain – NMR
RBBP7
3cfs, 3cfv – hRBBP7 + histone H4
RBBP9
2qs9 – hRBBP9
