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Sandbox 37

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Revision as of 23:36, 13 March 2012

Please do NOT make changes to this Sandbox. Sandboxes 30-60 are reserved for use by Biochemistry 410 & 412 at Messiah College taught by Dr. Hannah Tims during Fall 2012 and Spring 2013.

1 Interferon-β

Interferon-β

Introduction

History

Structure

Interferon-β is a relatively simple biological response modifier consisting of five . There are no beta sheets, but, in addition to the alpha helices, only multiple interconnecting . Helices A, B and D run , and helices C and E run to the other three helices. ^[1]

^[2]

Solvent Interactions

Mechanism

Inhibition

Inhibitors of Interferon-β

Interferon-β as an Inhibitor

Function

Biochemical

Immunological

References

↑ Kudo M. Management of hepatocellular carcinoma: from prevention to molecular targeted therapy. Oncology. 2010 Jul;78 Suppl 1:1-6. Epub 2010 Jul 8. PMID:20616576 doi:10.1159/000315222
↑ http://www.uniprot.org/uniprot/P00784

Retrieved from "http://52.214.119.220/wiki/index.php/Sandbox_37"

@@ Line 10: / Line 10: @@
 <StructureSection load='1IFA' size='400' align='right' caption='Interferon-β' scene='Sandbox_37/Interferon_beta/1'></StructureSection>
-Interferon-β is a relatively simple biological response modifier consisting of five <scene name='Sandbox_37/Ifnb_alpha_helices/1'>alpha helices</scene>. There are no beta sheets, but merely multiple interconnecting <scene name='Sandbox_37/Ifnb_loops/1'>loop regions</scene>.
+Interferon-β is a relatively simple biological response modifier consisting of five <scene name='Sandbox_37/Ifnb_alpha_helices/1'>alpha helices</scene>. There are no beta sheets, but, in addition to the alpha helices, only multiple interconnecting <scene name='Sandbox_37/Ifnb_loops/1'>loop regions</scene>. Helices A, B and D run <scene name='Sandbox_37/Ifnb_parallel_abd/1'>parallel to one another</scene>, and helices C and E run <scene name='Sandbox_37/Interferon_beta/3'>anti-parallel</scene> to the other three helices.
 <ref name="Structure">PMID:20616576</ref>