1bys
From Proteopedia
(New page: 200px<br /> <applet load="1bys" size="450" color="white" frame="true" align="right" spinBox="true" caption="1bys, resolution 2.0Å" /> '''CRYSTAL STRUCTURE OF...) |
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==About this Structure== | ==About this Structure== | ||
| - | 1BYS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]] with WO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BYS OCA]]. | + | 1BYS is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Salmonella_typhimurium Salmonella typhimurium]] with WO4 as [[http://en.wikipedia.org/wiki/ligand ligand]]. Structure known Active Site: ACT. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1BYS OCA]]. |
==Reference== | ==Reference== | ||
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[[Category: phosphodiesterase]] | [[Category: phosphodiesterase]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 13:01:10 2007'' |
Revision as of 10:56, 30 October 2007
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CRYSTAL STRUCTURE OF NUC COMPLEXED WITH TUNGSTATE
Overview
The first crystal structure of a phospholipase D (PLD) family member has, been determined at 2.0 A resolution. The PLD superfamily is defined by a, common sequence motif, HxK(x)4D(x)6GSxN, and includes enzymes involved in, signal transduction, lipid biosynthesis, endonucleases and open reading, frames in pathogenic viruses and bacteria. The crystal structure suggests, that residues from two sequence motifs form a single active site. A, histidine residue from one motif acts as a nucleophile in the catalytic, mechanism, forming a phosphoenzyme intermediate, whereas a histidine, residue from the other motif appears to function as a general acid in the, cleavage of the phosphodiester bond. The structure suggests that the, conserved lysine residues are involved in phosphate binding. ... [(full description)]
About this Structure
1BYS is a [Single protein] structure of sequence from [Salmonella typhimurium] with WO4 as [ligand]. Structure known Active Site: ACT. Full crystallographic information is available from [OCA].
Reference
Crystal structure of a phospholipase D family member., Stuckey JA, Dixon JE, Nat Struct Biol. 1999 Mar;6(3):278-84. PMID:10074947
Page seeded by OCA on Tue Oct 30 13:01:10 2007
