1duy
From Proteopedia
(New page: 200px<br /> <applet load="1duy" size="450" color="white" frame="true" align="right" spinBox="true" caption="1duy, resolution 2.15Å" /> '''CRYSTAL STRUCTURE O...) |
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caption="1duy, resolution 2.15Å" /> | caption="1duy, resolution 2.15Å" /> | ||
'''CRYSTAL STRUCTURE OF HLA-A*0201/OCTAMERIC TAX PEPTIDE COMPLEX'''<br /> | '''CRYSTAL STRUCTURE OF HLA-A*0201/OCTAMERIC TAX PEPTIDE COMPLEX'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1DUY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1DUY is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DUY OCA]. |
==Reference== | ==Reference== | ||
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[[Category: immunoglobulin fold]] | [[Category: immunoglobulin fold]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:40:53 2008'' |
Revision as of 13:40, 15 February 2008
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CRYSTAL STRUCTURE OF HLA-A*0201/OCTAMERIC TAX PEPTIDE COMPLEX
Contents |
Overview
The crystal structure of the human class I MHC molecule HLA-A2 complexed, with of an octameric peptide, Tax8 (LFGYPVYV), from human T cell, lymphotrophic virus-1 (HTLV-1) has been determined. This structure is, compared with a newly refined, higher resolution (1.8 A) structure of, HLA-A2 complexed with the nonameric Tax9 peptide (LLFGYPVYV) with one more, N-terminal residue. Despite the absence of a peptide residue (P1) bound in, the conserved N-terminal peptide-binding pocket of the Tax8/HLA-A2, complex, the structures of the two complexes are essentially identical., Water molecules in the Tax8 complex replace the terminal amino group of, the Tax9 peptide and mediate a network of hydrogen bonds among the, secondary structural elements at that end of the peptide-binding groove., Thermal denaturation measurements indicate that the Tax8 complex is much, less stable, DeltaTm = 16 degrees C, than the Tax9 complex, but both can, sensitize target cells for lysis by some Tax-specific CTL from HTLV-1, infected individuals. The absence of a P1 peptide residue is thus not, enough to prevent formation of a "closed conformation" of the, peptide-binding site. TCR affinity measurements and cytotoxic T cell, assays indicate that the Tax8/HLA-A2 complex does not functionally, cross-react with the A6-TCR-bearing T cell clone specific for Tax9/HLA-A2, complexes.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
1DUY is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The structure and stability of an HLA-A*0201/octameric tax peptide complex with an empty conserved peptide-N-terminal binding site., Khan AR, Baker BM, Ghosh P, Biddison WE, Wiley DC, J Immunol. 2000 Jun 15;164(12):6398-405. PMID:10843695
Page seeded by OCA on Fri Feb 15 15:40:53 2008
