1e3y
From Proteopedia
(New page: 200px<br /> <applet load="1e3y" size="450" color="white" frame="true" align="right" spinBox="true" caption="1e3y" /> '''DEATH DOMAIN FROM HUMAN FADD/MORT1'''<br />...) |
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'''DEATH DOMAIN FROM HUMAN FADD/MORT1'''<br /> | '''DEATH DOMAIN FROM HUMAN FADD/MORT1'''<br /> | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1E3Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1E3Y is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E3Y OCA]. |
==Reference== | ==Reference== | ||
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[[Category: fas receptor death inducing signalling complex]] | [[Category: fas receptor death inducing signalling complex]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:41:31 2008'' |
Revision as of 13:41, 15 February 2008
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DEATH DOMAIN FROM HUMAN FADD/MORT1
Overview
FADD (also known as MORT-1) is an essential adapter protein that couples, the transmembrane receptors Fas (CD95) and tumor necrosis factor, receptor-1 (TNF-R1) to intracellular cysteine proteases known as caspases, which propagate and execute the programmed cell death-inducing signal, triggered by Fas ligand (FasL, CD95L) and TNF. FADD contains 208 amino, acid residues, and comprises two functionally and structurally distinct, domains: an N-terminal death effector domain (DED) that promotes, activation of the downstream proteolytic cascade through binding of the, DED domains of procaspase-8; and a C-terminal death domain (DD). FADD-DD, provides the site of FADD recruitment to death receptor complexes at the, plasma membrane by, for example, interaction with the Fas receptor, cytoplasmic death domain (Fas-DD), or binding of the TNF-R1 adapter, molecule TRADD. We have determined the three-dimensional solution, structure and characterised the internal polypeptide dynamics of human, FADD-DD using heteronuclear NMR spectroscopy of (15)N and, (13)C,(15)N-labelled samples. The structure comprises six alpha-helices, joined by short loops and displays overall similarity to the death domain, of the Fas receptor. The analysis of the dynamic properties reveals no, evidence of contiguous stretches of polypeptide chain with increased, internal motion, except at the extreme chain termini. A pattern of, increased rates of amide proton solvent exchange in the alpha3 helix, correlates with a higher degree of solvent exposure for this secondary, structure element. The properties of the FADD-DD structure are discussed, with respect to previously reported mutagenesis data and emerging models, for FasL-induced FADD recruitment to Fas and caspase-8 activation.
About this Structure
1E3Y is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The three-dimensional solution structure and dynamic properties of the human FADD death domain., Berglund H, Olerenshaw D, Sankar A, Federwisch M, McDonald NQ, Driscoll PC, J Mol Biol. 2000 Sep 8;302(1):171-88. PMID:10964568
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