3rik

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'''Unreleased structure'''
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[[Image:3rik.jpg|left|200px]]
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The entry 3rik is ON HOLD until Paper Publication
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{{STRUCTURE_3rik| PDB=3rik | SCENE= }}
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Authors: Orwig, S.D., Lieberman, R.L.
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===The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease===
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Description: The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease
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{{ABSTRACT_PUBMED_22047104}}
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==About this Structure==
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[[3rik]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RIK OCA].
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==Reference==
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<ref group="xtra">PMID:022047104</ref><references group="xtra"/>
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[[Category: Glucosylceramidase]]
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[[Category: Homo sapiens]]
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[[Category: Lieberman, R L.]]
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[[Category: Orwig, S D.]]
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[[Category: Glycosylation]]
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[[Category: Hydrolase]]
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[[Category: Hydrolase-hydrolase inhibitor complex]]
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[[Category: Lysosomal hydrolase]]
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[[Category: Lysosome]]
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[[Category: Tim-barrel]]

Revision as of 06:38, 14 March 2012

Image:3rik.jpg

Template:STRUCTURE 3rik

The acid beta-glucosidase active site exhibits plasticity in binding 3,4,5,6-tetrahydroxyazepane-based inhibitors: implications for pharmacological chaperone design for gaucher disease

Template:ABSTRACT PUBMED 22047104

About this Structure

3rik is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

  • Orwig SD, Tan YL, Grimster NP, Yu Z, Powers ET, Kelly JW, Lieberman RL. Binding of 3,4,5,6-tetrahydroxyazepanes to the acid-beta-glucosidase active site: implications for pharmacological chaperone design for Gaucher disease. Biochemistry. 2011 Dec 13;50(49):10647-57. Epub 2011 Nov 14. PMID:22047104 doi:10.1021/bi201619z

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OCA

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