Anthrax edema factor
From Proteopedia
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| - | '''Anthrax edema factor''' (EF) is an enzyme which is part of the Bacillus anthracis anthrax toxin. The anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. It causes the cellular level of cAMP to increase thus upsetting water homeostasis and causing disruption of signaling pathways. | + | '''Anthrax edema factor''' (EF) is an enzyme which is part of the ''Bacillus anthracis'' anthrax toxin. The anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. It causes the cellular level of cAMP to increase thus upsetting water homeostasis and causing disruption of signaling pathways. |
==3D structures of anthrax edema factor== | ==3D structures of anthrax edema factor== | ||
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[[1xfw]] - EF residues 33-800 + calmodulin + cAMP<br /> | [[1xfw]] - EF residues 33-800 + calmodulin + cAMP<br /> | ||
[[1xfx]], [[1xfy]], [[1xfz]] - EF residues 33-800 + calmodulin | [[1xfx]], [[1xfy]], [[1xfz]] - EF residues 33-800 + calmodulin | ||
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Revision as of 12:04, 14 March 2012
Template:STRUCTURE 1xfw Anthrax edema factor (EF) is an enzyme which is part of the Bacillus anthracis anthrax toxin. The anthrax toxin is composed of a cell-binding protein (protective antigen), lethal factor and EF. The EF is a calcium- and calmodulin-dependent adenylate cyclase. It causes the cellular level of cAMP to increase thus upsetting water homeostasis and causing disruption of signaling pathways.
3D structures of anthrax edema factor
1lvc – EF adenylate cyclase domain + calmodulin + anthraniloyl-deoxy-ATP
1pk0 - EF adenylate cyclase domain + calmodulin + phosphonylmethoxyethyl-ADP
1s26 - EF adenylate cyclase domain + calmodulin + methylene-ATP
1sk6 - EF adenylate cyclase domain + calmodulin + pyrophosphate + cAMP
1xfu - EF residues 64-800 (mutant) + calmodulin
1xfv - EF residues 33-800 + calmodulin + deoxy-ATP
1xfw - EF residues 33-800 + calmodulin + cAMP
1xfx, 1xfy, 1xfz - EF residues 33-800 + calmodulin
