Pyridoxine 5'-phosphate oxidase
From Proteopedia
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| + | {{STRUCTURE_1nrg| PDB=1nrg | SIZE=400| SCENE= |right|CAPTION=Human pyridoxine 5'-phosphate oxidase containing FMN complex with pyridoxine 5'-phosphate , [[1nrg]] }} | ||
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Revision as of 07:32, 18 March 2012
Pyridoxine 5’-phosphate oxidase (PPO) catalyzes the oxidation of pyridoxamine-phosphate by molecular oxygen producing pyridoxal 5’-phosphate, ammonia and hydrogen peroxide. pyridoxal 5’-phosphate (PLP), commonly known as vitamin B6, which is a biological essential cofactor. PPO catalyzes the last step in vitamin B6 metabolism. PPO uses FMN as cofactor.
1dnl, 1g76, 1wv4 – EcPPO – Escherichia coli
1g76, 1g77, 1g78, 1g79, 1jnw – EcPPO + PLP
1nrg - hPPO + PLP – human
3hy8 - hPPO (mutant) + PLP
2aq6 - PPO + PLP – Mycobacterium tuberculosis
