NADH peroxidase
From Proteopedia
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| - | {{STRUCTURE_2npx| PDB=2npx | SIZE=400| SCENE= |right|CAPTION=NADH peroxidase complex with NAD, [[2npx]] }} | + | {{STRUCTURE_2npx| PDB=2npx | SIZE=400| SCENE= |right|CAPTION=NADH peroxidase containing FAD complex with NAD, [[2npx]] }} |
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Revision as of 07:31, 19 March 2012
NADH peroxidase (NPO) catalyzes the conversion of NADH to NAD+ using hydrogen peroxide. NPO eliminates the potentially toxic hydrogen peroxide and defends the cell against H2O2-mediated oxidative stress. NPO provides an additional pathway for regeneration of NAD+ which is essential to the fermentative metabolism. FAD is the cofactor in this reaction.
3D structures of NADH peroxidase
1npx, 1joa – EfNPO – Enterococcus faecalis
2npx – EfNPO + NAD
1nhp, 1nhq, 1nhr, 1nhs, 1f8w – EfNPO (mutant)
