3hxo
From Proteopedia
(Difference between revisions)
m (Protected "3hxo" [edit=sysop:move=sysop]) |
|||
| Line 13: | Line 13: | ||
<!-- | <!-- | ||
| - | The line below this paragraph, {{ | + | The line below this paragraph, {{ABSTRACT_PUBMED_19913482}}, adds the Publication Abstract to the page |
| - | (as it appears on PubMed at http://www.pubmed.gov), where | + | (as it appears on PubMed at http://www.pubmed.gov), where 19913482 is the PubMed ID number. |
--> | --> | ||
| - | {{ | + | {{ABSTRACT_PUBMED_19913482}} |
==About this Structure== | ==About this Structure== | ||
| Line 22: | Line 22: | ||
==Reference== | ==Reference== | ||
| - | <ref group="xtra">PMID: | + | <ref group="xtra">PMID:019913482</ref><ref group="xtra">PMID:018025536</ref><ref group="xtra">PMID:019422452</ref><references group="xtra"/> |
[[Category: Homo sapiens]] | [[Category: Homo sapiens]] | ||
[[Category: Diener, J L.]] | [[Category: Diener, J L.]] | ||
| Line 32: | Line 32: | ||
[[Category: Arc1772]] | [[Category: Arc1772]] | ||
[[Category: Arc1779]] | [[Category: Arc1779]] | ||
| - | [[Category: Blood clotting | + | [[Category: Blood clotting-blood clotting regulator complex]] |
[[Category: Blood coagulation]] | [[Category: Blood coagulation]] | ||
[[Category: Cell adhesion]] | [[Category: Cell adhesion]] | ||
| Line 43: | Line 43: | ||
[[Category: Isopeptide bond]] | [[Category: Isopeptide bond]] | ||
[[Category: Platelet glycoprotein ib]] | [[Category: Platelet glycoprotein ib]] | ||
| - | [[Category: Polymorphism]] | ||
[[Category: Secreted]] | [[Category: Secreted]] | ||
| - | [[Category: Ubl conjugation]] | ||
[[Category: Von willebrand disease]] | [[Category: Von willebrand disease]] | ||
[[Category: Vwf]] | [[Category: Vwf]] | ||
Revision as of 06:11, 21 March 2012
Crystal Structure of Von Willebrand Factor (VWF) A1 Domain in Complex with DNA Aptamer ARC1172, an Inhibitor of VWF-Platelet Binding
Template:ABSTRACT PUBMED 19913482
About this Structure
3hxo is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
- Huang RH, Fremont DH, Diener JL, Schaub RG, Sadler JE. A structural explanation for the antithrombotic activity of ARC1172, a DNA aptamer that binds von Willebrand factor domain A1. Structure. 2009 Nov 11;17(11):1476-84. PMID:19913482 doi:10.1016/j.str.2009.09.011
- Gilbert JC, DeFeo-Fraulini T, Hutabarat RM, Horvath CJ, Merlino PG, Marsh HN, Healy JM, Boufakhreddine S, Holohan TV, Schaub RG. First-in-human evaluation of anti von Willebrand factor therapeutic aptamer ARC1779 in healthy volunteers. Circulation. 2007 Dec 4;116(23):2678-86. Epub 2007 Nov 19. PMID:18025536 doi:10.1161/CIRCULATIONAHA.107.724864
- Diener JL, Daniel Lagasse HA, Duerschmied D, Merhi Y, Tanguay JF, Hutabarat R, Gilbert J, Wagner DD, Schaub R. Inhibition of von Willebrand factor-mediated platelet activation and thrombosis by the anti-von Willebrand factor A1-domain aptamer ARC1779. J Thromb Haemost. 2009 Jul;7(7):1155-62. Epub 2009 Apr 24. PMID:19422452 doi:10.1111/j.1538-7836.2009.03459.x
Categories: Homo sapiens | Diener, J L. | Fremont, D H. | Huang, R H. | Sadler, J E. | Schaub, R G. | Aptamer | Arc1772 | Arc1779 | Blood clotting-blood clotting regulator complex | Blood coagulation | Cell adhesion | Cleavage on pair of basic residue | Disease mutation | Disulfide bond | Extracellular matrix | Glycoprotein | Hemostasis | Isopeptide bond | Platelet glycoprotein ib | Secreted | Von willebrand disease | Vwf
