This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1f2q
From Proteopedia
(New page: 200px<br /> <applet load="1f2q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1f2q, resolution 2.40Å" /> '''CRYSTAL STRUCTURE O...) |
|||
| Line 1: | Line 1: | ||
| - | [[Image:1f2q. | + | [[Image:1f2q.jpg|left|200px]]<br /><applet load="1f2q" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1f2q" size=" | + | |
caption="1f2q, resolution 2.40Å" /> | caption="1f2q, resolution 2.40Å" /> | ||
'''CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR'''<br /> | '''CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR'''<br /> | ||
| Line 8: | Line 7: | ||
==About this Structure== | ==About this Structure== | ||
| - | 1F2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with NAG as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1F2Q is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=NAG:'>NAG</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1F2Q OCA]. |
==Reference== | ==Reference== | ||
| Line 23: | Line 22: | ||
[[Category: receptor]] | [[Category: receptor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri Feb 15 15:45:24 2008'' |
Revision as of 13:45, 15 February 2008
|
CRYSTAL STRUCTURE OF THE HUMAN HIGH-AFFINITY IGE RECEPTOR
Overview
Allergic responses result from the activation of mast cells by the human, high-affinity IgE receptor. IgE-mediated allergic reactions may develop to, a variety of environmental compounds, but the initiation of a response, requires the binding of IgE to its high-affinity receptor. We have solved, the X-ray crystal structure of the antibody-binding domains of the human, IgE receptor at 2.4 A resolution. The structure reveals a highly bent, arrangement of immunoglobulin domains that form an extended convex surface, of interaction with IgE. A prominent loop that confers specificity for IgE, molecules extends from the receptor surface near an unusual arrangement of, four exposed tryptophans. The crystal structure of the IgE receptor, provides a foundation for the development of new therapeutic approaches to, allergy treatment.
About this Structure
1F2Q is a Single protein structure of sequence from Homo sapiens with as ligand. Full crystallographic information is available from OCA.
Reference
Crystal structure of the human high-affinity IgE receptor., Garman SC, Kinet JP, Jardetzky TS, Cell. 1998 Dec 23;95(7):951-61. PMID:9875849
Page seeded by OCA on Fri Feb 15 15:45:24 2008
